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Transcriptome-wide RNA 5-methylcytosine profiles of human iPSCs and iPSC-derived cardiomyocytes. [PDF]

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Chen SY, Fang YH, Huang CY, Wu JH, Shan YS, Liu YW, Huang PH.   +6 more
europepmc   +1 more source

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Advances in mapping the epigenetic modifications of 5‐methylcytosine (5mC), N6‐methyladenine (6mA), and N4‐methylcytosine (4mC)

Biotechnology and Bioengineering, 2021
DNA modification plays a pivotal role in regulating gene expression in cell development. As prevalent markers on DNA, 5‐methylcytosine (5mC), N6‐methyladenine (6mA), and N4‐methylcytosine (4mC) can be recognized by specific methyltransferases ...
Hao Lv, Fu-Ying Dao, Dan Zhang
exaly   +2 more sources

Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues

Mutation Research - Reviews in Genetic Toxicology, 1990
Methylation of cytosine residues at position 5 is the only known genetically programmed modifica- tion of the bases in vertebrate DNA. 5-Methylcy- tosine (mSC) constitutes - 0.7-3% of the bases of all studied normal vertebrate cells or tissues and is found mostly in CpG dinucleotide sequences (Ehrlich and Wang, 1981; Gama-Sosa ...
Melanie Ehrlich, Xian-Yang Zhang
exaly   +3 more sources

5-Methylcytosine in Eukaryotic DNA

Science, 1981
A small portion of the cytosine residues in the DNA of higher eukaryotes as well as in that of many lowe eukaryotes if methylated. The resulting 5-methylcytosine residues occur in specific in the DNA, usually adjacent to guanine residues on the 3' side.
M, Ehrlich, R Y, Wang
openaire   +2 more sources

5-Methylcytosine-Rich Heterochromatin in Reptiles

Cytogenetic and Genome Research, 2019
An experimental approach using monoclonal anti-5-methylcytosine antibodies and indirect immunofluorescence was elaborated for detecting 5-methylcytosine-rich chromosome regions in reptilian chromosomes. This technique was applied to conventionally prepared mitotic metaphases of 2 turtle species and 12 squamate species from 8 families.
Michael Schmid, Claus Steinlein, Alina M. Reiter, Michail Rovatsos, Marie Altmanová, Sofia Mazzoleni, Martina Johnson Pokorná, Lukáš Kratochvíl   +7 more
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FLUORESCENCE OF 5‐METHYLCYTOSINE

Photochemistry and Photobiology, 1970
Abstract— 5‐Methylcytosine and 5‐methyldeoxycytidylic acid are fluorescent in aqueous solution at room temperature and neutral pH. 5‐Methylcytosine, 10‐3M, pH 8.5, 25°C, has a quantum yield of 5 ×10‐4, 5‐Methyldeoxycitydylic acid, 10‐4M, pH 7.5, 20°C, has a quantum yield of 8 × 10‐4. Emission maxima are 2.91 and 2.80μ‐1.
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5-Methylcytosine in Chlorella pyrenoidosa DNAs

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
The presence of 5-methylcytosine in Chlorella pyrenoidosa (strain 211/8b) DNA's has been investigated by means of paper chromatography and thermal chromatography on hydroxyapatite. It has been shown that nuclear DNA contains 3.5 mol% 5-methylcytosine whereas no significant amount of this base can be detected in chloroplast DNA.
M, Bayen, J, Dalmon
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On the mechanism of demethylation of 5-methylcytosine in DNA

Bioorganic & Medicinal Chemistry Letters, 2008
DNA methylation is an important biological process that programmes gene expression in vertebrates. The methylation pattern is generated by a combination of methylation and demethylation reactions catalyzed by DNA methyltransferases and putative demethylases. MBD2 binds methylated DNA and possesses DNA demethylase activity.
Stefan, Hamm, George, Just, Nathalie, Lacoste, Nicolas, Moitessier, Moshe, Szyf, Orval, Mamer   +5 more
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OsNSUN2-Mediated 5-Methylcytosine mRNA Modification Enhances Rice Adaptation to High Temperature.

Developmental Cell, 2020
Extreme weather events can cause heat stress that decreases crop production. Recent studies have demonstrated that protein degradation and rRNA homeostasis as well as transcription factors are involved in the thermoresponse in plants.
Yongyan Tang, Chunchun Gao, Ying Gao, Ying Yang, B. Shi, Jia-Li Yu, Cong Lyu, Bao-Fa Sun, Hailin Wang, Yunyuan Xu, Yun-Gui Yang, K. Chong   +11 more
semanticscholar   +1 more source