Results 71 to 80 of about 2,171 (168)

Distribution of 5mC (blue) and 5hmC (pink) levels across regions.

, 2015
The lowest median levels of both are in 5’UTR’s, however, beyond that there is little correlation between 5mC and 5hmC levels. Median 5hmC levels are similar across all regions, while 5mC levels show greater variation.
Dario Beraldi (121970), Shankar Balasubramanian (9301), Sarah F. Field (695149), Martin Bachman (695150), Stephan Beck (5246), Sabrina K. Stewart (695151)   +5 more
core   +1 more source

Tissue-specific 5-hydroxymethylcytosine landscape of the human genome

Nature Communications, 2021
Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-
Bo He, Chao Zhang, Xiaoxue Zhang, Yu Fan, Hu Zeng, Jun’e Liu, Haowei Meng, Dongsheng Bai, Jinying Peng, Qian Zhang, Wei Tao, Chengqi Yi   +11 more
doaj   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Formation of 5hmC following exposure to Ionizing Radiation

, 2014
GSI Scientific Report 2013 - GSI Report 2014 ...
Herrlitz, M., Natale, F., Leifke, A. L., Durante, M., Taucher-Scholz, G.   +4 more
openaire   +2 more sources

Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma [PDF]

Human Molecular Genetics, 2018
Aberrant DNA hypermethylation is a hallmark of cancer although the underlying molecular mechanisms are still poorly understood. To study the possible role of 5-hydroxymethylcytosine (5hmC) in this process we analyzed the global and locus-specific genome-wide levels of 5hmC and 5-methylcytosine (5mC) in human primary samples from 12 non-tumoral brains ...
Agustin F Fernandez, Gustavo F Bayón, Marta I Sierra, Rocio G Urdinguio, Estela G Toraño, Maria G García, Antonella Carella, Virginia López, Pablo Santamarina, Raúl F Pérez, Thalía Belmonte, Juan Ramon Tejedor, Isabel Cobo, Pablo Menendez, Cristina Mangas, Cecilia Ferrero, Luis Rodrigo, Aurora Astudillo, Ignacio Ortea, Sergio Cueto Díaz, Pablo Rodríguez-Gonzalez, J Ignacio García Alonso, Manuela Mollejo, Bárbara Meléndez, Gemma Domínguez, Felix Bonilla, Mario F Fraga   +26 more
openaire   +6 more sources

Cell cycle-dependent change in the 5hmC content.

, 2013
A. The 5hmC content in mESCs treated with aphidicolin, hydroxyurea, serum depletion, or nocodazole was determined by β-GT assaying. The values represent the fold change normalized as to that without treatment. The values for each treatment are averages ±
Shoji Tajima (12397), Isao Suetake (495206), Haruhiko Koseki (15970), Yuichi Mishima (495204), Jafar Sharif (147235), Junji Otani (495203), Masahiro Shirakawa (16613), Toru Kawakami (495205), Takaho A. Endo (147216), Hironobu Kimura (135869)   +9 more
core   +1 more source

The Cell Type–Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia [PDF]

, 2022
The conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) is a key step in DNA demethylation that is mediated by ten–eleven translocation (TET) enzymes, which require ascorbate/vitamin C.
Ediriwickrema, Asiri, Ning, Yuhong, Köhnke, Thomas, Majeti, Ravindra, Ellison, Christopher, Ku, Chin-Jen, Corces, M, Kaur, Satinder, Azizi, Armon, Martinez-Krams, Daniel, Guler, Gulfem, Cruz Hernandez, David, Guler, Gulfem D., Fan, Amy, Nakauchi, Yusuke, Phan, Paul, Levy, Samuel, Reinisch, Andreas, Dutta, Ritika, Thomas, Daniel, Stafford, Melissa, Sharma, Rajiv, Bergamaschi, Anna, Phillips, Tierney, Karigane, Daiki, McCarthy, Erin, Ellison, Christopher K., Corces, M. Ryan   +27 more
core   +1 more source

Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in endometrioid adenocarcinoma and its clinical significance

BMC Women's Health
Background Aberrant DNA methylation is a vital molecular alteration commonly detected in type I endometrial cancers (EC), and tet methylcytosine dioxygenase 2 (TET2) and 5-hydroxymethylcytosine (5hmC) play significant roles in DNA demethylation. However,
Lei Kuang, Jingbo Zhang, Yanyu Li, Qing Wang, Jianwei Liu, Bei Zhang   +5 more
doaj   +1 more source

5-Hydroxymethylcytosine in circulating cell-free DNA as a potential diagnostic biomarker for SLE

Lupus Science and Medicine
Background SLE is a complex autoimmune disease with heterogeneous manifestations and unpredictable outcomes. Early diagnosis is challenging due to non-specific symptoms, and current treatments only manage symptoms.
Nan Wang, Yuan Xu, Wenwen Chen, Xinya Tong, Lele Ye, Yanling Xiong, Yunhui Luo, Xinhang Xia, Zexia Xu, Yutong Lin, Xinqi Zhu, Xiangyang Xue, Huidi Zhang, Gangqiang Guo   +13 more
doaj   +1 more source

Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma

npj Genomic Medicine, 2021
The 5-methylcytosines (5mC) have been implicated in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). However, the role of 5-hydroxymethylcytosines (5hmC) that are generated from 5mC through active demethylation, in ...
Brian C.-H. Chiu, Chang Chen, Qiancheng You, Rudyard Chiu, Girish Venkataraman, Chang Zeng, Zhou Zhang, Xiaolong Cui, Sonali M. Smith, Chuan He, Wei Zhang   +10 more
doaj   +1 more source