Results 81 to 90 of about 2,171 (168)
The Journal of Physiology, EarlyView.Abstract figure legend Pregestational stress modifies germ‐cell epigenetic information, resulting in GABAergic dysfunction and E/I imbalance in the developing brain, thereby increasing susceptibility to ASD‐and ADHD‐related neurodevelopmental abnormalities in offspring.
Samaneh Ahmadian‐Moghadam +2 more
wiley +1 more source
, 2015 5hmC levels are highest at intermediate levels of 5mC (~40%).
Dario Beraldi (121970) +5 more
core +1 more source
Advanced Materials Technologies, Volume 11, Issue 12, 18 June 2026.ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali +4 more
wiley +1 more source
Molecular Oncology, 2021 Approximately 85% colorectal cancers (CRCs) are thought to evolve through the adenoma‐to‐carcinoma sequence associated with specific molecular alterations, including the 5‐hydroxymethylcytosine (5hmC) signature in circulating cell‐free DNA (cfDNA).
ZeWen Xiao +17 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Postoperative delirium (POD) is common in older surgical patients and is clinically associated with an increased risk of long‐term cognitive decline and dementia; disrupted BDNF signaling and circadian dysregulation are implicated, but their coordinated mechanisms remain unclear.
Hari Prasad Osuru +7 more
wiley +1 more source
Distribution of 5hmC among adipose tissue nuclei.
, 2016 IFM and FNC were used to examine 5hmC levels among visceral adipose tissue nuclei. A. A field of VAT nuclei examined with various combinations of DAPI staining for DNA, and immunostaining with mouse anti-PPARg2 + goat anti-mouse Alexafluor488 and rabbit ...
Ping Yu (215536) +10 more
core +1 more source
Acta Neuropathologica Communications, 2023 Background Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult patients. Elucidating novel transcriptomic and epigenetic contributors to the molecular heterogeneity underlying its ...
Chang Zeng +8 more
doaj +1 more source
Genomic distribution of 5hmC in P1 and adult cardiomyocytes.
, 2016 (A) Overlap of P1 and adult 5hmC peaks obtained from MACS2 peak calling. Common peaks were defined as P1 and adult peaks sharing at least 50% of their respective length. (B) Annotation of P1, common and adult (from top to bottom) 5hmC peaks obtained from
Thomas G. Nührenberg (758785) +5 more
core +1 more source
5-hydroxymethylcytosine is highly dynamic across human fetal brain development
BMC Genomics, 2017 Background Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system.
Helen Spiers +4 more
doaj +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 2, June 2026.Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source