Results 91 to 100 of about 2,171 (168)
5-Hydroxymethylcytosine profilings in circulating cell-free DNA as diagnostic biomarkers for DLBCL
Frontiers in Cell and Developmental BiologyBackground5-Hydroxymethylcytosine (5hmC) is an important DNA epigenetic modification that plays a vital role in tumorigenesis, progression and prognosis. Previous studies have shown that it plays an important role in the prognosis of diffuse large B-cell
Hangyu Chen +4 more
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Human Genomics, 2020 5-Methylcytosine (5mC) is considered as a common epigenetic modification that plays an important role in the regulation of gene expression. At the same time, 5-hydroxymethylcytosine (5hmC) has been found as an emerging modification of cytosine bases of ...
Tianmin Xu, Haoyue Gao
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Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis: An Exploratory Study
Journal of Clinical Periodontology, Volume 53, Issue 6, Page 911-923, June 2026.ABSTRACT Aim Salivary microvesicles (MVs) are nanosized extracellular vesicles from the host and microbiota whose cargo may mirror the biological state of their parent cells. This cross‐sectional study aimed to explore the diagnostic power of host methylome and microbiome profiles of MVs in various periodontal disease states. Materials and Methods This
Pingping Han +5 more
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Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk
Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin +2 more
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, 2012 Patients with anaplastic astroyctoma (A) or adults with glioblastoma (B) were stratified with respect to 5hmC staining level into 5hmC-low (first quartile) and 5hmC-high tumors (quartiles 2–4).
Brent A. Orr (150119) +4 more
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Advances in Visualizing Cytosine Methylation and Allele‐Specific Epigenetic States in Tissue Context
Pathology International, Volume 76, Issue 6, June 2026.The ICON method enables sequence‐specific, bisulfite‐free visualization of DNA methylation through chemical recognition of methylated cytosines. Following probe hybridization under mild denaturing conditions, methylation‐dependent interstrand complexes are stabilized by covalent crosslinking.
Sohei Kitazawa +2 more
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Materials Today BioTen-eleven translocation (TET) proteins orchestrate deoxyribonucleic acid (DNA) methylation-demethylation dynamics by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and are frequently inactivated in various cancers.
Habibulla Imran +5 more
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5hmC enrichment statistics in mouse brain and liver tissues.
, 2017 (A) The distribution of the size of 5hmC enriched regions in the 12 samples. (B) The percentage genome that is 5hmC-enriched. The per-chromosome 5hmC enrichment of the (C) intragenic regions and (D) intergenic regions in brain and liver samples.
Yi-Fan Chen (403450) +2 more
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5hmC Promotes Glioblastomagenesis via Modulation of Gene Expression [PDF]
Cancer Discovery, 2014 Abstract Epigenetic changes induced by TET1-mediated 5hmC production are required for glioblastomagenesis.
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Enrichment of 5mC and 5hmC in specific promoters.
, 2013 5hmC (blue bars) and 5mC (red bars) were determined by DNA microarray analysis in the promoters of the Pcdha gene cluster (A), maternal imprinting genes (B), and HoxA gene cluster (C). The abscissas indicate enrichment of 5hmC or 5mC on a log2 scale.
Shoji Tajima (12397) +9 more
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