Results 111 to 120 of about 2,171 (168)
5hmC marks LMRs in a cell-type specific fashion.
, 2013 (A) Average profiles for methylation (WG-BisSeq), 5hmC (hMeDIP-seq) and TET1 occupancy at Fully Methylated, Unmethylated and Low Methylated Regions (FMRs, UMRs and LMRs, respectively) in ES cells. (B) DNA methylation (upper tracks) and enrichment of 5hmC
Dimos Gaidatzis (160945) +5 more
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, 2016 The epigenetic DNA modification 5-hydroxymethylcytosine (5hmC) has crucial roles in development and gene regulation. Quantifying the abundance of this epigenetic mark at the single-cell level could enable us to understand its roles.
Dey, Siddharth S +11 more
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Clinical EpigeneticsBackground 5-Hydroxymethylcytosine (5hmC) modification represents a significant epigenetic modification within DNA, playing a pivotal role in a range of biological processes associated with various types of cancer. The role of 5hmC in systemic anaplastic
Ziqing Yu +7 more
doaj +1 more source
5hmC dynamics during differentiation occurs preferentially at LMRs.
, 2013 (A–B) Shown is the relative frequency of changes in 5hmC at LMRs and UMRs normalized for genome coverage at the ES (A) and NP state (B). The y-axis shows observed linear fold enrichment relative to expected enrichments (see Materials and Methods).
Dimos Gaidatzis (160945) +5 more
core +1 more source
Predicting gene expression state and prioritizing putative enhancers using 5hmC signal
Genome BiologyBackground Like its parent base 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) is a direct epigenetic modification of cytosines in the context of CpG dinucleotides.
Edahi Gonzalez-Avalos +4 more
doaj +1 more source
ELUCIDATION OF MECHANISMS GENERATING 5-HYDROXYMETHYLCYTOSINE (5hmC) IN MAMMALIAN MITOCHONDRIA
, 2013 DNA methylation plays a pivotal role in governing cellular processes including genomic imprinting, gene expression, and development. Recently, the Tet family of methylcytosine dioxygenases(Tet1, Tet2 and Tet3) was found to catalyze the oxidation of 5 ...
Thakkar, Prashant
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Epigenetic landscape of 5-hydroxymethylcytosine and associations with gene expression in placenta
Epigenetics5-hydroxymethylcystosine (5hmC), is an intermediate product in the DNA demethylation pathway, but may act as a functional epigenetic modification. We have conducted the largest study of site-specific 5hmC in placenta to date using parallel bisulphite and
Michael Mortillo +4 more
doaj +1 more source
Decoding 5HMC as an Active Chromatin Mark in the Brain and its Link to Rett Syndrome
, 2013 Functions of the nervous system are accompanied at the cellular level by changes in gene expression, regulated by transcription factors and epigenetic mechanisms, such as histone modifications and DNA methylation, that are frequently altered in ...
Ayata, Pinar
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5hmC levels are reduced in the germinal regions of the human fetal forebrain.
, 2012 Fetal brain sections were stained with hematoxylin and eosin (A-C) and evaluated for 5hmC or TET2 levels using immunohistochemistry. Sections of the forebrain germinal region stained with antibodies for 5hmC (D) showed markedly reduced levels.
Brent A. Orr (150119) +4 more
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Communications MedicineBackground Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. This study investigates the roles of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal ...
Fabio Puddu +16 more
doaj +1 more source