Results 131 to 140 of about 2,171 (168)
Global loss of 5hmC in primary renal cell carcinoma and metastases.
, 2016 (A) Normal kidney tissue shows uniformly strong staining for 5hmC in tubules and glomerular cells. (B) Clear cell renal cell carcinoma exhibit greatly reduced 5hmC levels (arrows).
Enrico Munari (750218) +10 more
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npj Parkinson's Disease5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic modifications increasingly recognized for their roles in Parkinson’s disease (PD). In this study, we profiled 5mC and 5hmC in blood samples from individuals with PD to explore their
Philipp Antczak +5 more
doaj +1 more source
A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations
, 2016 We present a highly sensitive and selective chemical labeling and capture approach for genome-wide profiling of 5-hydroxylmethylcytosine (5hmC) using DNA isolated from similar to 1,000 cells (nano-hmC-Seal).
You, Qiancheng +8 more
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Role of TET3 and 5hmC in the small intestinal epithelium homeostasis
, 2022 The Ten-eleven translocation (TET) enzymes oxidize the DNA base 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). This DNA hydroxymethylation process generates a stable epigenetic mark, the 5hmC, that is able to regulate gene transcription. In fact, TET proteins and the 5hmC modification are relevant during embryonic development and cellular ...
openaire +1 more source
Genome-wide quantification of 5hmC in single cells [PDF]
Nature Reviews Genetics, 2016 openaire +1 more source
Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson’s disease and age ...
Scaife, Paula +2 more
openaire
The effect of chemoenzymatic 5hmc derivatization on dna polymerase readouts
DNA modifications, particularly the epigenetic marks 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), play critical roles in gene regulation, embryonic and disease development, including cancer. Despite its biological importance, the detection and mapping of 5hmC remain technically challenging due to its chemical similarity to 5 ...
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Investigating 5-Hydroxymethylcytosine (5hmC): The State of the Art
, 2013 The discovery of 5-hydroxymethylcytosine (5hmC) as an abundant base in mammalian genomes has excited the field of epigenetics, and stimulated an intense period of research activity aimed at decoding its biological significance. However, initial research efforts were hampered by a lack of assays capable of specifically detecting 5hmC.
Colm E, Nestor +3 more
openaire +3 more sources
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Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease
FASEB Journal, 2020Abstract 5‐hydroxymethylcytosine (5hmC) is an intermediate stage of DNA de‐methylation. Its location in the genome also serves as an important regulatory signal for many biological processes and its levels change significantly with the etiology of Alzheimer's disease (AD).
Kaiyu Xu, Hei-Man Chow, Karl Herrup
exaly +3 more sources
MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System
Cell, 2012 The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic stem cells.
Pinar Ayata +2 more
exaly +2 more sources