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5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors [PDF]
International Journal of Molecular Sciences, 2019 This study aimed to validate whether 5-hydroxymethylcytosine (5hmC) level in combination with ERG expression is a predictive biomarker for biochemical failure (BF) in men undergoing radical prostatectomy (RP) for prostate cancer (PCa). The study included
Gitte Kristensen +2 more
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Cancer Letters, 2019
DNA hypermethylation is a driving force in carcinogenesis. However, the role of active DNA hypomethylation in cancer remains largely unknown. This process, facilitated by ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which oxidizes 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5hmC), has never been studied in cervical cancer. Here,
Po-Hsuan Su +10 more
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DNA hypermethylation is a driving force in carcinogenesis. However, the role of active DNA hypomethylation in cancer remains largely unknown. This process, facilitated by ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which oxidizes 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5hmC), has never been studied in cervical cancer. Here,
Po-Hsuan Su +10 more
openaire +2 more sources
Practical Guidelines and Consideration of Using RRHP for 5hmC Detection
Epigenomics, 20165-hydroxymethylcytosine (5hmC) is an epigenetic modification, which has been associated with gene expression in many biological contexts. Reduced representation hydroxymethylation profiling was developed as an enzymatic-based method for genome-wide 5hmC detection.
Xueguang, Sun +3 more
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TROP-2, 5hmC, and IDH1 Expression in Anaplastic Thyroid Carcinoma
International Journal of Surgical Pathology, 2020Background Anaplastic thyroid carcinoma (ATC), a highly aggressive malignancy, has no effective treatment to date. Trophoblast cell-surface antigen 2 (TROP-2), a transmembrane glycoprotein, has been suggested to be a promising novel target for sacituzumab govitecan, an antibody-drug conjugate.
Jae Yeon Seok +4 more
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[The expression and significance of TET gene and 5hmC in chronic rhinosinusitis].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery, 2021Objective:To investigate the expression and clinical significance of TET gene and 5hmC in chronic sinusitis. Methods:Acquiring 20 cases of nasal polyps from chronic sinusitis with polyps（CW）, 20 cases of uncinate process tissues from chronic sinusitis without polyps（CS）, 10 cases of middle turbinate tissues from patients with nasal septum deviated as ...
Chong, Yao, Yu, Xu
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Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq
Nature BiotechnologyDynamic 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) modifications to DNA regulate gene expression in a cell-type-specific manner and are associated with various biological processes, but the two modalities have not yet been measured simultaneously from the same genome at the single-cell level.
Dongsheng Bai +5 more
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5hmC Distribution in Isolated Visceral Adipose Tissue Nuclei
The FASEB Journal, 2016The reprogramming of specific cell types, and in visceral adipocytes in particular, is likely to be a fundamental to obesity and its related comorbidities. We explored the hypothesis that adipose tissue contains epigenetically distinct subpopulations of adipocytes in that are differentially potentiated to record
Ping Yu +7 more
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[Expression and clinical significance of 5hmC in bladder urothelial carcinoma].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2016To investigate the expression of 5-hydroxymethylcytosine (5hmC) in bladder urothelial carcinoma (UC) and its clinical significance.The expression of 5hmC in 21 cases of UC tissues and pericarcinous urinary tract epithelium was detected by immunohistochemical staining.
Jie, Li +6 more
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Wogonin Inhibits Ovarian Cancer by Activating the AMPK‐TET2‐5hmC Axis
Molecular CarcinogenesisABSTRACTOvarian cancer is one of the most common gynecologic cancers. In the quest for effective anti‐cancer agents, this study explores the effects of wogonin, a naturally occurring flavonoid, on the viability and migration of A2780 and Kuramochi ovarian cancer cells. A2780 and Kuramochi human ovarian cancer cell lines were utilized.
Shu‐Yi Yang +10 more
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