Results 121 to 130 of about 2,171 (168)

The adult human brain contains relatively high levels of 5hmC.

, 2012
Sections from multiple regions in the pediatric and adult human brain were stained for hematoxylin and eosin (A-D) and by immunohistochemistry for 5hmC (E–F). Both the pediatric and adult brain showed relatively strong staining for 5hmC in grey matter of
Brent A. Orr (150119), Charles G. Eberhart (150132), Michael C. Haffner (27579), William G. Nelson (27581), Srinivasan Yegnasubramanian (27577)   +4 more
core   +1 more source

5hmC enrichment profile similarity among the 12 mouse samples.

, 2017
(A) An unsorted similarity matrix of intragenic 5hmC coverage. The colors represent the correlation scores (i.e., similarity) ranging from dark blue (ρ = 0.5) to dark red (ρ = 1.0). (B) Visualization of the genomic region around Xist.
Yi-Fan Chen (403450), I-Hsuan Lin (169850), Ming-Ta Hsu (48445)   +2 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Effect of number of replicates on 5hmC detection.

, 2015
Top left: Number of probes detected as differentially methylated, i.e. as hydroxymethylated (having a positive 5hmC signal), with all four replicates and with only replicates 1 and 3. Top right: Using only replicates 2 and 4.
Dario Beraldi (121970), Shankar Balasubramanian (9301), Sarah F. Field (695149), Martin Bachman (695150), Stephan Beck (5246), Sabrina K. Stewart (695151)   +5 more
core   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

MNase stratification reveals heterogeneous 5hmC in naive B cells

Abstract DNA demethylation is essential for gene activation and is primarily mediated by the Ten-Eleven-Translocation (TET) dioxygenase family. TET initiates the demethylation by oxidizing 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), a chemically stable derivative that is not only an intermediate in demethylation but also ...
Michael Hsu, Heng-Yi Chen, Fang-Yun Lay, Qin Ma, Ben Delatte, Chan-Wang Jerry Lio   +5 more
openaire   +2 more sources

Global 5hmC levels in normal testis and testicular neoplasms.

, 2016
(A) Sertoli cells (arrowheads) show strong immunoreactivity in normal testicular tubules. (B) Low 5hmC staining in intratubular germ cell neoplasia (ITGCN) of the testis (arrows). (C) Representative seminoma case with low nuclear 5hmC staining.
Enrico Munari (750218), Nilda Gonzalez Roibon (846474), Stephania M. Bezerra (843055), Ajay M. Vaghasia (846471), Alcides Chaux (5666497), Diana Taheri (846472), George J. Netto (843066), Sarah Karram (846473), Michael C. Haffner (27579), William G. Nelson (27581), Srinivasan Yegnasubramanian (27577)   +10 more
core   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science
Somatic cell nuclear transfer (SCNT) embryos exhibit widespread epigenetic defects, particularly aberrant DNA methylation. DNA 5‐hydroxymethylcytosine (5hmC) is involved in methylation reprogramming during early embryonic development, yet its role in ...
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
doaj   +1 more source

Structural biology of 5hmC-specific endonuclease PvuRts1I [PDF]

Acta Crystallographica Section A Foundations and Advances, 2015
Asgar Abbas Kazrani, Monika Kowalska, Honorata Czapinska, Matthias Bochtler   +3 more
openaire   +1 more source

5hmC enrichment in relation to intragenic regions across 12 samples.

, 2017
We evaluate the intragenic 5hmC enrichment patterns in (A) protein-coding genes, (B) process transcripts, (C) lincRNAs, (D) enzymes, (E) G-protein coupled receptors, (F) kinases (G), others, (H) transcription regulators and (I) transporters.
Yi-Fan Chen (403450), I-Hsuan Lin (169850), Ming-Ta Hsu (48445)   +2 more
core   +1 more source