Results 151 to 160 of about 9,556,040 (196)

Microsomal Hydroxylation and Glucuronidation of [6]-Gingerol

Journal of Agricultural and Food Chemistry, 2006
[6]-Gingerol is the major pungent principle of ginger and frequently is ingested with various condiments and nutritional supplements. We report here that incubation of [6]-gingerol with NADPH-fortified rat hepatic microsomes gave rise to eight metabolites, which were tentatively identified by GC-MS analysis as two products of aromatic hydroxylation as ...
Pfeiffer, E., Heuschmid, F. F., Kranz, S., Metzler, M.   +3 more
openaire   +2 more sources

The active part of the [6]-gingerol molecule in mutagenesis

Mutation Research Letters, 1983
A study was performed to discover the active part in mutagenesis of [6]-gingerol, a mutagen contained in ginger Zingiber officinale (Nakamura and Yamamoto, 1982). [6]-Shogaol was isolated from the ginger by column chromatography on silica gel. [6]-Shogaol was much less mutagenic (1 X 10(3) revertants/10(8) viable cells/700 microM) than [6]-gingerol (1 ...
H, Nakamura, T, Yamamoto
openaire   +2 more sources

Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats

Biopharmaceutics and Drug Disposition, 2008
Abstract[6]‐Gingerol is one of the pungent components in ginger which has been found to possess various pharmacological effects. However, there is insufficient information on the properties of [6]‐gingerol based on controlled pharmacokinetic studies.
Sui-Qing Mi, Ning-Sheng Wang
exaly   +3 more sources

Control of membrane biofouling by 6-gingerol analogs: Quorum sensing inhibition

Fuel, 2019
Biofouling is a major problem in operating reverse osmosis (RO) processes. Although biocides such as chlorine are commonly used to reduce biofouling, their strong oxidative activity and toxicity negatively affect the operation of RO processes. 6-gingerol
Jeong-Hoon Park, So-Young Ham, Youngjoo Byun   +2 more
exaly   +2 more sources

Synthesis of chiral difluorinated [6]-gingerol

Tetrahedron, 1996
Abstract Total synthesis of chiral difluorinated [6]-gingerol using key intermediates ( R )-(+)- and ( S )-(−)-ethyl 2,2-difluoro-3-hydroxyoctanoates, obtained via enzymatic resolution with olipase/4S ( Rhizopus japonicus ) is described.
H. Fukuda, M. Tetsu, T. Kitazume
openaire   +1 more source

Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol

Cancer Letters, 1998
[6]-Gingerol, a major pungent ingredient found in the rhizome of ginger, has been reported to possess a strong antiinflammatory activity, which is considered to be closely associated with its cancer chemopreventive potential. [6]-Paradol, another pungent
Young-Joon Surh, Eunsong Lee, Y J Surh
exaly   +2 more sources

Stages in the biosynthesis of [6]-gingerol in zingiber Officinale

Journal of the Chemical Society, Chemical Communications, 1979
[2-14C,3H,3-3H]Dihydroferulic acid and [1-14C,6-3H]hexanoic acid are shown to be incorporated into (S)-[6]-gingerol in Zingiber officinale, the 3H/14C ratio falling by ½ in the first case but remaining constant in the second; a biogenetic scheme is proposed to accommodate these results, and includes discussion of the late stages of biosynthesis in the ...
Ian Macleod, Donald A. Whiting
openaire   +1 more source

Comparison of the nephroprotective effect of [6]-gingerol and the [6]-gingerol-β-cyclodextrin complex against cisplatin-induced AKI

Naunyn-Schmiedeberg's Archives of Pharmacology
Cisplatin is an antineoplastic agent effective for the treatment of several cancers. However, due to its nephrotoxicity, its use is limited. Acute kidney injury (AKI) induced by cisplatin is caused by inflammation, apoptosis, and oxidative stress in renal tubular cells.
Dayara, de Oliveira Silva, Mikael Almeida, Lima, Thiago Miranda, de Freitas, Francisco Cleber Silva, Ferreira, Antônio Klingem Leite, de Freitas, Mário Rogério Lima, Mota, James Almada, da Silva, Marco Antonio, de Freitas Clementino, Alexandre, Havt   +8 more
openaire   +2 more sources

Sulfation of 6-Gingerol by the Human Cytosolic Sulfotransferases: A Systematic Analysis

Planta Medica, 2015
Previous studies have demonstrated the presence of the sulfated form of 6-gingerol, a major pharmacologically active component of ginger, in plasma samples of normal human subjects who were administered 6-gingerol. The current study was designed to systematically identify the major human cytosolic sulfotransferase enzyme(s) capable of mediating the ...
Lijun, Luo, Xue, Mei, Yuecheng, Xi, Chunyang, Zhou, Ying, Hui, Katsuhisa, Kurogi, Yoichi, Sakakibara, Masahito, Suiko, Ming-Cheh, Liu   +8 more
openaire   +2 more sources

Genotoxic effect of 6-gingerol on human hepatoma G2 cells

Chemico-Biological Interactions, 2010
6-gingerol, a major component of ginger, has antioxidant, anti-apoptotic, and anti-inflammatory activities. However, some dietary phytochemicals possess pro-oxidant effects as well, and the risk of adverse effects is increased by raising the use of doses.
Guang, Yang, Laifu, Zhong, Liping, Jiang, Chengyan, Geng, Jun, Cao, Xiance, Sun, Yufang, Ma   +6 more
openaire   +2 more sources