6-Shogaol inhibits HSCs activation and liver fibrosis by regulating glycolytic reprogramming via targeting HIF-1α [PDF]
Chinese MedicineBackground Liver fibrosis is a representative scarring response that can ultimately lead to liver cancer. However, relevant antifibrotic drugs for the effective treatment of liver fibrosis in humans have not yet been identified. 6-Shogaol is derived from
Junfa Yang +7 more
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Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
Pharmaceuticals, 2021 Ginger (Zingiber officinale Roscoe) is widely used as medicinal plant. According to the Committee on Herbal Medicinal Products (HMPC), dried powdered ginger rhizome can be applied for the prevention of nausea and vomiting in motion sickness (well ...
Robert Fürst, Iris Bischoff-Kont
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Pharmaceutics, 2019 ：6-shogaol is a promising anti-cancer and anti-inflammatory agent. However, the treatment effectiveness of 6-shogaol is limited by poor water solubility, poor oral absorption and rapid metabolism.
Jiangnan Yu, Wenwen Deng, Hui Yun Zhang
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Inhibitory effect of [6]-shogaol against 3CLpro activity and SARS-CoV-2 infection [PDF]
BMC Complementary Medicine and TherapiesBackground Zingiber officinale Roscoe (ginger) has been traditionally used not only as a culinary ingredient, but also for its medicinal properties.
Takashi Tanikawa +5 more
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Albumin Nanoparticles Harness Activated Neutrophils to Cross Vascular Barriers for Targeted Subcutaneous and Orthotopic Colon Cancer Therapy [PDF]
Journal of Functional BiomaterialsColorectal cancer (CRC) therapy faces challenges due to limited drug penetration across the blood–tumor barrier. Neutrophils, with their natural ability to migrate to inflamed and tumor sites, offer a promising cell-mediated delivery strategy. This study
Zhifan Luo +3 more
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Spatial Profiling of Gingerol and Shogaol Analogues in Intact Zingiber officinale Rhizomes Using MALDI Mass Spectrometry Imaging [PDF]
MoleculesGinger (Zingiber officinale) is a widely recognized functional food, known for its anti-inflammatory, antioxidant, and digestive health benefits largely attributed to gingerol-related compounds.
Josie C. Torrecampo +7 more
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Frontiers in Pharmacology, 2022 Rhizomes from Zingiber officinale Roscoe are traditionally used for the treatment of a plethora of pathophysiological conditions such as diarrhea, nausea, or rheumatoid arthritis.
Iris Bischoff-Kont +5 more
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Molecules, 2021 Acute kidney injury (AKI) is a dose-limiting side effect of cisplatin therapy in cancer patients. However, effective therapies for cisplatin-induced AKI are not available.
Mi-Gyeong Gwon +3 more
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6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. [PDF]
PLoS ONE, 2012 6-Shogaol is an active compound isolated from Ginger (Zingiber officinale Rosc). In this work, we demonstrated that 6-shogaol induces apoptosis in human hepatocellular carcinoma cells in relation to caspase activation and endoplasmic reticulum (ER ...
Rong Hu +10 more
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Anticancer effects of 6-shogaol via the AKT signaling pathway in oral squamous cell carcinoma
Journal of Applied Oral Science, 2021 Objective Oral squamous cell carcinoma (OSCC) is one of the common type of cancer that leads to death; and is becoming a global concern. Due to the lack of efficient chemotherapeutic agents for patients with oral cancer, the prognosis remains poor.
Hai HUANG, Myoung-Ok KIM, Ki-Rim KIM
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