6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation [PDF]
Folia Histochemica et Cytobiologica, 2023 INTRODUCTION: Sepsis is characterized by an overactive inflammatory response. Acute lung injury (ALI) is the most common type of organ injury in sepsis, with high morbidity and mortality.
Quanli Pan, Peng Liu, Min Wan
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The Effect of 6-Gingerol on Human AML Cell Lines
Cellular Physiology and BiochemistryBackground/Aims: Acute myeloid leukemia (AML) is a devastating hematological malignancy without a definitive cure. 6-Gingerol, a bioactive compound, has shown promise in treating various cancers, yet its impact on AML remains elusive.
Tingting Zhang +7 more
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Unraveling the interconversion pharmacokinetics and oral bioavailability of the major ginger constituents: [6]-gingerol, [6]-shogaol, and zingerone after single-dose administration in rats [PDF]
Frontiers in PharmacologyBackgroundThe available in vitro evidences suggest the inherent instability and interconvertibility of [6]-gingerol and [6]-shogaol. However, limited data on their in vivo interconversion hinder understanding of their influence on the pharmacokinetic ...
Phanit Songvut +8 more
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Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Candida albicans is an opportunistic pathogen and responsible for candidiasis. C. albicans readily forms biofilms on various biotic and abiotic surfaces, and these biofilms can cause local and systemic infections. C.
Jin-Hyung Lee +5 more
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Progress in Research on the Health Effects and Mechanisms of 6-Gingerol and in Development of Oral Delivery Systems for It [PDF]
Shipin Kexue, 2023 6-Gingerol is the major pungent component in ginger. It possesses a variety of health benefits including antitumor, anti-inflammatory and antioxidant, hypoglycemic, hypolipidemic and hypotensive activities as well as colitis prevention and treatment ...
TIAN Wenni, SONG Mingyue, LÜ Muwen, WANG Qun, CAO Yong, XIAO Jie
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Frontiers in Pharmacology, 2022 Numerous studies have elucidated the neuroprotective effect of 6-gingerol in central nervous system diseases. However, the potential role and mechanism of 6-gingerol on early brain injury (EBI) after subarachnoid hemorrhage (SAH) remains poorly ...
Hui Tang +11 more
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Cells, 2023 Iron homeostasis is considered a key factor in human metabolism, and abrogation in the system could create adverse effects, including cancer. Moreover, 6-gingerol is a widely used bioactive phenolic compound with anticancer activity, and studies on its ...
Dong Young Kang +6 more
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Cardioprotection by 6-gingerol in diabetic rats [PDF]
Biochemical and Biophysical Research Communications, 2016 The current study was conducted to evaluate the effect of 6-gingerol (6G) on cardiac complications in streptozotocin (STZ)-induced diabetic (DM) rats. STZ-induced DM rats (single 50 mg/kg i.p. injection, 15 days prior to drug treatment) or time-matched controls were treated with 6G (75 mg/day route orally).
El-Bassossy, Hany M. +5 more
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Gingerol and shogaol on red ginger rhizome (Zingiber officinale var. Rubrum) using high-performance liquid chromatography [PDF]
Pharmaciana, 2023 Red ginger (Zingiber officinale var. Rubrum) is one of the traditional medicines of the Zingiberaceae family, which contains phenolic ketone compounds, including gingerol and shogaol.
Johan Sukweenadhi +4 more
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Biological Properties of 6-Gingerol: A Brief Review [PDF]
Natural Product Communications, 2014 Numerous studies have revealed that regular consumption of certain fruits and vegetables can reduce the risk of many diseases. The rhizome of Zingiber officinale (ginger) is consumed worldwide as a spice and herbal medicine. It contains pungent phenolic substances collectively known as gingerols.
Shaopeng, Wang +3 more
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