Protective Effect of Amber Extract on Human Dopaminergic Cells against 6-Hydroxydopamine-Induced Neurotoxicity [PDF]
Molecules, 2022 Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, after Alzheimer’s disease. In our previous study, we found that amber—a fossilized plant resin—can protect cells from apoptosis by decreasing the generation of ...
Yuening Luo +5 more
doaj +2 more sources
Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells [PDF]
Neural Regeneration Research, 2022 Ghrelin is a neuropeptide that has various physiological functions and has been demonstrated to be neuroprotective in a number of neurological disease models. However, the underlying mechanisms of ghrelin in Parkinson’s disease remain largely unexplored.
Xin He +6 more
doaj +2 more sources
The c-Abl/p73 pathway induces neurodegeneration in a Parkinson's disease model
IBRO Neuroscience Reports, 2022 Parkinson's disease is the second most common neurodegenerative disorder. Although it is clear that dopaminergic neurons degenerate, the underlying molecular mechanisms are still unknown, and thus, successful treatment is still elusive. One pro-apoptotic
Tamara Marín +7 more
doaj +1 more source
The pre-teatment effect of voluntary exercise by GDNF on lesion injectioned by 6- hydroxydopamine in brain stem of male rats Abstract [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2014 Background&Purpose: The purpose of this research was to investigate the protective effect of voluntary exercise by GDNF on lesion induced by 6-hydroxydopamine in brainstem of male rats.
راضیه محمدی +3 more
doaj +1 more source
Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Progressive loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) in Parkinson’s disease (PD) leads to impairment of motor skills. Several evidences show that the role of serotonergic system in regulation of normal movement is
Safar Farajnia +2 more
doaj +1 more source
Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration [PDF]
, 2016 Background: Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel ...
Antonioli, Luca +13 more
core +3 more sources
Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat parkinsonism. [PDF]
, 2012 published_or_final_versio
Chan, YS +4 more
core +12 more sources
PLoS ONE, 2011 BackgroundIn addition to their original applications to lowering cholesterol, statins display multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely with the dopaminergic system and are strongly implicated in therapeutic
Junqiang Yan +12 more
doaj +1 more source
Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]
, 2016 Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano +3 more
core +2 more sources
Protective effect of tetrahydroxystilbene glucoside on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway. [PDF]
PLoS ONE, 2011 Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease. The molecule, 2,3,5,4'-tetrahydr- oxystilbene-2-O-β-D-glucoside (TSG), is a potent antioxidant derived from the Chinese herb ...
Lizhen Tao +9 more
doaj +1 more source