6-Hydroxydopamine induces mitochondrial ERK activation [PDF]
Free Radical Biology and Medicine, 2007 Reactive oxygen species (ROS) are implicated in 6-hydroxydopamine (6-OHDA) injury to catecholaminergic neurons; however, the mechanism(s) are unclear. In addition to ROS generated during autoxidation, 6-OHDA may initiate secondary cellular sources of ROS that contribute to toxicity.
Scott M, Kulich +3 more
openaire +2 more sources
Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans [PDF]
, 2014 Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra.
A Garcia-Espana +75 more
core +5 more sources
Nrf2-mediated protection against 6-hydroxydopamine [PDF]
Brain Research, 2007 Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by cell loss in the substantia nigra resulting in striatal dopamine depletion. Although the cause of sporadic PD is unknown, oxidative stress is thought to contribute to disease pathogenesis. One mechanism by which cells defend themselves against oxidative stress is through
Rebekah J, Jakel +3 more
openaire +2 more sources
Neural Regeneration Research, 2018 Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson’s disease animal models. They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra, but also satisfy the requirements for iron deposition ...
Lan-Xiang Liu +9 more
doaj +1 more source
The hepatic sympathetic nerve plays a critical role in preventing Fas induced liver injury in mice [PDF]
, 2005 Background: Although previous studies have shown that the hepatic sympathetic nerve controls various physiological functions in the liver, the role of this nerve in liver injury has yet to be clarified.Aims: The purpose of this study was to elucidate the
Chida, Y, Kubo, C, Sudo, N, Takaki, A
core +1 more source
Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back [PDF]
, 2018 Clinical and research studies have suggested a link between Parkinson\u2019s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD.
Bisaglia, Marco +3 more
core +1 more source
Comparative cytotoxicity study of nicotine and cotinine on MRC-5 cell line [PDF]
, 2018 Nicotine has several health hazards regarding carcinogenic potential. It also imparts increased risk for respiratory, cardiovascular, and gastrointestinal disorders.
Baconi, Daniela Luiza +4 more
core +4 more sources
BMC Complementary Medicine and Therapies, 2022 Background Parkinson’s disease (PD) is a multifactorial movement disorder with the progressive degeneration of the nigrostriatal system that impairs patients’ movement ability. Oxidative stress has been found to affect the etiology and pathogenesis of PD.
Saeideh Nourmohammadi +5 more
doaj +1 more source
Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain [PDF]
, 2010 The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer, Jeremy Paul
core +1 more source
Intermittent theta-burst stimulation rescues dopamine-dependent corticostriatal synaptic plasticity and motor behavior in experimental parkinsonism. Possible role of glial activity. [PDF]
, 2017 Background: Recent studies support the therapeutic utility of repetitive transcranial magnetic stimulation in Parkinson's disease (PD), whose progression is correlated with loss of corticostriatal long-term potentiation and long-term depression.
Cacace, Fabrizio +15 more
core +2 more sources