The beneficial effect of the flavonoid quercetin on behavioral changes in hemi-Parkinsonian rats
Basic and Clinical Neuroscience, 2010 Introduction: A large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson's disease (PD).
Mehdi Mehdizadeh +3 more
doaj +2 more sources
Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease [PDF]
, 2016 AIMS: Current therapies in Parkinson's disease mainly treat symptoms rather than provide effective neuroprotection. We examined the effects of safinamide (monoamine oxidase B and sodium channel blocker) on microglial activation and the degeneration of ...
Mullali, G +5 more
core
Silk fibroin‐based biomaterials for spinal cord injury repair: Recent advances and future prospects
BMEMat, EarlyView.A comprehensive review on the design principles and current strategies of silk fibroin‐based biomaterials in spinal cord injury repair, focusing on environmentally friendly processing techniques, and the strategies for designing composite scaffolds as well as discussing the advantages and current challenges of silk fibroin‐based biomaterials in spinal ...
Xiaoliang Cui +7 more
wiley +1 more source
The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons [PDF]
, 2014 6-hydroxydopamine (6-OHDA) is one of the most commonly used toxins for modeling degeneration of dopaminergic (DA) neurons in Parkinson's disease. 6-OHDA also causes axonal degeneration, a process that appears to precede the death of DA neurons.
Harmon, Steve +4 more
core +2 more sources
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
High-frequency stimulation of the subthalamic nucleus counteracts cortical expression of major histocompatibility complex genes in a rat model of Parkinson's disease. [PDF]
PLoS ONE, 2014 High-frequency stimulation of the subthalamic nucleus (STN-HFS) is widely used as therapeutic intervention in patients suffering from advanced Parkinson's disease.
Benjamin Grieb +11 more
doaj +1 more source
Role of movement in long-term basal ganglia changes: implications for abnormal motor responses [PDF]
, 2013 Abnormal involuntary movements (AIMs) and dyskinesias elicited by drugs that stimulate dopamine receptors in the basal ganglia are a major issue in the management of Parkinson’s disease (PD).
FRAU, LUCIA +3 more
core +1 more source
Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou +6 more
wiley +1 more source
Evaluation of Chlorogenic Acid in Parkinson’s Disease Model: An In-vitro Study in 6-OHDA Induced SH-SY5Y Cell Line [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Parkinson’s Disease (PD) is the most common neurodegenerative movement disorder. Mitochondrial dysfunction is a key pathological driver of PD.
Sunprakathi Alwarsamy Perumalsamy +3 more
doaj +1 more source
Ibrain, EarlyView.In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard +2 more
wiley +1 more source