Results 61 to 70 of about 32,355 (207)

Lack of tolerance for the anti-dyskinetic effects of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in rats [PDF]

, 2010
7-Nitroindazole (7-NI) inhibits neuronal nitric oxide synthase in vivo and reduces l-DOPA-induced dyskinesias in a rat model of parkinsonism. The aim of the present study was to determine if the anti-dyskinetic effect of 7-NI was subject to tolerance ...
DA-SILVA, C.A., DEL BEL, E.A., NOVARETTI, N., PADOVAN-NETO, F.E., TUMAS, V.   +4 more
core   +2 more sources

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Prolonged intermittent theta burst stimulation restores the balance between A2AR- and A1R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson’s disease

Neural Regeneration Research
An imbalance in adenosine-mediated signaling, particularly the increased A2AR-mediated signaling, plays a role in the pathogenesis of Parkinson’s disease. Existing therapeutic approaches fail to alter disease progression, demonstrating the need for novel
Milica Zeljkovic Jovanovic, Jelena Stanojevic, Ivana Stevanovic, Milica Ninkovic, Tihomir V. Ilic, Nadezda Nedeljkovic, Milorad Dragic   +6 more
doaj   +1 more source

Effect of Biarum carduchrum extract on brain tissue thiol level in rat model of 6-hydroxydopamine-induced Parkinson’s disease [PDF]

, 2018
Introduction: Parkinson’s disease (PD) is developed due to the degeneration of dopaminergic neurons in the substantia nigra, which is widely associated with oxidative stress. The reduction of glutathione, as the most abundant and important tissue thiol
Setorki, Mahbubeh., Zanganehnejad, Zahra.   +1 more
core   +2 more sources

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Pre-treatment Effects of Eriobotrya Japonica Extraction on Malondialdehyde (MDA), Brain-Derived Neurotrophic Factor (BDNF), and Superoxide Dismutase (SOD) Levels in Hippocampus of Parkinsonian Rats Induced by 6-hydroxydopamine Following 12 weeks of Volunt

مجله دانشکده پزشکی اصفهان, 2014
Background: The purpose of this study was to investigate the effects of extract of Eriobotrya japonica flower on brain-derived neurotrophic factor (BDNF), superoxide dismutase (SOD), and malondialdehyde (MDA) levels in the hippocampus of Parkinsonian ...
Zia Fallah Mohammadi, Razieh Mohammadi, Jalil Aslani   +2 more
doaj  

Neuroprotective Effect of Voluntary Wheel Running Exercise on GDNF levels of Cerebellum in Parkinsonian Rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2012
Introduction: Parkinson's disease is caused by disorder in control centers of body and leads to vibration at rest, bradykinesia, tremor, muscular rigidity and postural imbalance. The disease occures due to the loss of midbrain dopaminergic cells.
فریده آبادیان, ضیاء فلاح محمدی   +1 more
doaj   +1 more source

Tunicate‐Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age‐Associated Vocal Fold Atrophy

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
The pyrogallol‐conjugated carboxymethylcellulose (CMC‐PG) hydrogel is applicated as a filler for the treatment of presbylaryngis, a vocal fold atrophy. CMC‐PG provides a bulking effect to the vocal folds. CMC‐PG is readily injectable and tissue adhesive, enabling sustained release of growth factor over long period.
Jihoon Jeon, Sang‐Yoon Han, Ji Suk Choi, Soojeong Choi, Dongkyun Shin, Mikyung Shin, Seong Keun Kwon, Seung‐Woo Cho   +7 more
wiley   +1 more source

Step Sequence is a Critical Gait Parameter of Unilateral 6-OHDA Parkinson's Rat Models

Cell Transplantation, 2017
Parkinson's disease is a progressive neurological disorder, marked by the loss of dopaminergic neurons in the nigrostriatal pathway that leads to abnormal gait, rigidity, slowness of movement, and tremor.
Heather A. Baldwin, Pyry P. Koivula, Julie C. Necarsulmer, Keith W. Whitaker, Brandon K. Harvey   +4 more
doaj   +1 more source