Electroacupuncture Produces the Sustained Motor Improvement in 6-Hydroxydopamine-Lesioned Mice. [PDF]
PLoS ONE, 2016 Clinical and research evidence has shown that electroacupuncture (EA) promotes recovery of motor function in patients with Parkinson's disease (PD). However, the "efficacy span" of EA treatment, especially the long-term effect of EA that is thought to ...
Yan Yu +5 more
doaj +1 more source
FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]
, 2014 The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca +2 more
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Neurotrophic effects of growth/differentiation factor 5 in a neuronal cell line [PDF]
, 2011 The neurotrophin growth/differentiation factor 5 (GDF5) is studied as a potential therapeutic agent for Parkinson's disease as it is believed to play a role in the development and maintenance of the nigrostriatal system.
Collins, Grace C. +2 more
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Brain and Behavior, Volume 16, Issue 2, February 2026.In Parkinson's disease, the death of dopamine neurons in the substantia nigra, resulting in a decrease in dopamine levels in the striatum. This leads to striatal damage through the HMGB1/RAGE/NF‐κB signaling pathway, thereby inducing motor and cognitive dysfunction.
Yaofeng Zhu +7 more
wiley +1 more source
A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death
Redox Biology, 2020 Recent findings suggest that dopamine oxidation contributes to the development of Parkinson's disease (PD); however, the mechanistic details remain elusive.
Ali Farzam +6 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Polysaccharides play a pivotal role in the development of safe and healthy foods. They ameliorate fatigue, preserve the microflora of the gastrointestinal tract, and provide health for the gut in living organisms. These biopolymers are applied for the fabrication of breakthrough drug delivery systems and potential platforms in regenerative medicine ...
M V N L Chaitanya +14 more
wiley +1 more source
The Protective Effect of Voluntary Exercise on the Hippocampal Cerebral Dopamine Neurotrophic Factor Level against Intraventricular Injection of 6-hydroxydopamine in Rats [PDF]
, 2014 : Background & Aims: The purpose of this research was to study the protective effect of pretreatment with a voluntary exercise on hippocampal level of cerebral dopamine neurotrophic factor (CDNF) after damage induced by intraventricular injection of 6 ...
Zia Fallah-Mohammadi, Ph.D., Jalil Aslani, M.Sc., Razieh Mohamma,
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Neurotrophic factors for the treatment of Parkinson's disease [PDF]
, 2011 Parkinson's disease (PD) is a common neurodegenerative disorder caused by the progressive degeneration of the nigrostriatal dopaminergic pathway. The resulting loss of dopamine neurotransmission is responsible for the symptoms of the disease.
Sullivan, Aideen M., Toulouse, André
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The Ontogenetic Development of Rapid Eye Movement Sleep in Early Life and Its Regulatory Mechanisms
International Journal of Developmental Neuroscience, Volume 86, Issue 1, February 2026.REM sleep was first identified in humans and cats in the late 1950s and exhibits a conserved developmental trajectory across species. This study elucidates key characteristic changes during REM sleep development, thereby providing a foundation for improving the prevention and treatment of various neurodevelopmental disorders.
Xiu‐Juan Zhang +8 more
wiley +1 more source
Memory-enhancing activities of the aqueous extract of Albizia adianthifolia leaves in the 6-hydroxydopamine-lesion rodent model of Parkinson’s disease [PDF]
, 2014 BACKGROUND: Albizia adianthifolia (Schumach.) W. Wright (Fabaceae) is a traditional herb largely used in the African traditional medicine as analgesic, purgative, anti-inflammatory, antioxidant, antimicrobial and memory-enhancer drug.
Alain Bertrand Dongmo +8 more
core +1 more source