Results 121 to 130 of about 8,386,191 (259)

Dexamethasone/vincristine pulses significantly reduce administered doses of 6MP/MTX during maintenance therapy in childhood acute lymphoblastic leukemia

EJC Paediatric Oncology
Background: Maintenance therapy with 6-Mercaptopurine (6MP) and Methotrexate (MTX) with or without dexamethasone (DEX) and vincristine (VCR) pulses, is crucial in childhood acute lymphoblastic leukaemia (ALL).
Valérie de Haas, Esmee Slot, Laura van den Berg, Rana Dandis, Hester de Groot-Kruseman, Rob Pieters   +5 more
doaj   +1 more source

Tumor Microenvironment-Responsive 6-Mercaptopurine-Releasing Injectable Hydrogel for Colon Cancer Treatment. [PDF]

Gels, 2023
Kim S, Lee W, Park H, Kim K.
europepmc   +1 more source

Exploring the Enhanced Antiproliferative Activity of Turmeric Oil and 6-Mercaptopurine in a Combined Nano-Particulate System Formulation. [PDF]

Pharmaceutics, 2023
Ahmed TA, Ali EMM, Kalantan AA, Almehmady AM, El-Say KM.   +4 more
europepmc   +1 more source

Some Perspectives on Immunosuppressive Drugs [PDF]

, 1967
In conclusion, the antimetabolites have proven extremely interesting in the laboratory for the exploration of the mechanism of antibody synthesis and related problems.
Schwartz, Robert S.
core   +1 more source

Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial. [PDF]

Clin Transl Gastroenterol, 2023
Swanson GR, Biglin M, Raff H, Chouhan V, Jochum S, Shaikh M, Francey L, Bishehsari F, Hogenesch J, Keshavarzian A.   +9 more
europepmc   +1 more source

Cephalothin as a Carrier of 6-Mercaptopurine for Targeting Cancer Tissues

Iraqi Journal of Pharmaceutical Sciences, 2017
A lower extracellular pH is one of the few well-documented physiological differences between tumour and normal tissues. On the other hand, elevated glutathione (GSH) level has been detected in many tumours compared with healthy surrounding tissues.
Mohammad H. Mohammad, Haider J.Al-Karagully   +1 more
doaj  

Early Initiation of Adalimumab Significantly Diminishes Postoperative Crohn's Disease Endoscopic Recurrence and Is Superior to 6-Mercaptopurine Therapy: An Open-Label, Randomized Controlled Study. [PDF]

J Clin Med, 2023
Hirsch A, Scapa E, Fliss-Isakov N, Tulchinsky H, Itzkowitz E, Kariv Y, Ron Y, Yanai H, White I, Yassin S, Cohen NA, Brazovski E, Dotan I, Maharshak N.   +13 more
europepmc   +1 more source

The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia. [PDF]

HGG Adv, 2023
Nguyen ML, Hoang AV, Duong BT, Phung NTN.   +3 more
europepmc   +1 more source

Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study

Haematologica
Allopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism.
Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek   +10 more
doaj   +1 more source

Commensal bacteria promote azathioprine therapy failure in inflammatory bowel disease via decreasing 6-mercaptopurine bioavailability. [PDF]

Cell Rep Med, 2023
Yan Y, Wang Z, Zhou YL, Gao Z, Ning L, Zhao Y, Xuan B, Ma Y, Tong T, Huang X, Hu M, Fang JY, Cui Z, Chen H, Hong J.   +14 more
europepmc   +1 more source