Results 191 to 200 of about 8,386,191 (259)

6-Mercaptopurine (purinethol).

Srpski arhiv za celokupno lekarstvo, 2003
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Smart co-delivery of 6-mercaptopurine and methotrexate using disulphide-based PEGylated-nanogels for effective treatment of breast cancer

New Journal of Chemistry, 2019
Smart co-delivery of 6-mercaptopurine and methotrexate using disulphide-based PEGylated-nanogels.
Parinaz Nezhad-Mokhtari, Marjan Ghorbani, F. Mahmoodzadeh   +2 more
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6-Mercaptopurine in Immunological Responsiveness

Nature, 1960
Schwartz and Dameshek1,2 have reported the apparent production of immunological tolerance in rabbits by the administration of a purine analogue, 6-mercaptopurine. Rabbits receiving concomitantly human serum albumin and 6-mercaptopurine failed to develop an immune response to the protein antigen, and weeks later, when antigen alone was administered, the
J L, ROBINSON, C L, CHRISTIAN
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IMMUNODEPRESSANT ACTIVITY AND 6-MERCAPTOPURINE LEVELS AFTER ADMINISTRATION OF 6-MERCAPTOPURINE AND AZATHIOPRINE

Transplantation, 1973
SUMMARY A comparative study of the immunosuppressive activities of 6-mercaptopurine and its derivative azathioprine has been performed. It has been shown that in mice and rats, 6-mercaptopurine is markedly superior to azathioprine in reducing the number of spleen hemolytic plaque-forming cells when injected by parenteral routes, whereas azathioprine ...
F, Spreafico, M G, Donelli, A, Bossi, A, Vecchi, S, Standen, S, Garattini   +5 more
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Comparative pharmacokinetics of oral 6‐mercaptopurine and intravenous 6‐mercaptopurine riboside in children

Pediatrics International, 2001
Abstract Background : The poor absorption of orally administered 6‐mercaptopurine (6MP) causes a wide variation in its cytotoxic efficacy. An i.v. dosage form would eliminate this problem. Our objective was to compare the pharmacokinetics of 6MP administered orally with those of an i.v.
H, Mawatari, K, Unei, S, Nishimura, N, Sakura, K, Ueda   +4 more
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A screen printed electrode modified with Fe3O4@polypyrrole-Pt core-shell nanoparticles for electrochemical detection of 6-mercaptopurine and 6-thioguanine.

Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2021
S. Tajik, H. Beitollahi, Ho Won Jang, M. Shokouhimehr   +3 more
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Teratogen update: Azathioprine and 6‐mercaptopurine

Teratology, 2002
Azathioprine (AZA) and its active metabolite, 6-mercaptopurine (6-MP), are purine analogues that interfere with the synthesis of adenine and guanine ribonucleosides. These ribonucleosides are important precursors of DNA and RNA. Because AZA and 6-MP act predominantly on rapidly dividing cells such as the T lymphocytes, these drugs are not only ...
Janine E, Polifka, J M, Friedman
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Zinc forms of faujasite zeolites as a drug delivery system for 6-mercaptopurine

Microporous and Mesoporous Materials, 2022
Marcel Jakubowski, M. Kucińska, M. Ratajczak, Monika Pokora, M. Murias, A. Voelkel, M. Sandomierski   +6 more
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6-Mercaptopurine Therapy

2007
6-Mercaptopurine (6-MP) and its parent drug azathioprine (AZA) are well known for their immunosuppressive and lymphocytotoxic properties. These antimetabolite drugs have been shown to suppress disease activity in up to 70% of children with moderate to severe IBD; among these patients, 50% will achieve a clinical response after 4 months of continuous ...
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