Results 31 to 40 of about 8,386,191 (259)
Marine Drugs, 2018 For enhanced intracellular accumulation of 6-mercaptopurine (6-MP) in leukemia, a folate receptor-targeted and glutathione (GSH)-responsive polymeric prodrug nanoparticle was made.
Xuan Wei +10 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2019 Background: Acute lymphoblastic leukemia (ALL) is the most common cancer seen in children worldwide and in the Middle East. Although there have been major advances in treatment approaches for childhood ALL, serious toxicities do occur but with ...
B. Moradveisi +5 more
semanticscholar +1 more source
Cyclophosphamide: An Alternative Treatment in Crohn’s Disease
Canadian Journal of Gastroenterology, 1989 lmmunosuppressive therapy in the form of 6-mercaptopurine has shown a 66% efficacy in severe, debilitating, highly corticosteroid dependent Crohn’s disease. Nevertheless this medication has some important side effects such as nausea, vomiting, leukopenia
Gilles Lapointe, Aubin Charbonneau
doaj +1 more source
Crystal structures of five 6-mercaptopurine derivatives
Acta Crystallographica Section E: Crystallographic Communications, 2016 The crystal structures of five 6-mercaptopurine derivatives, viz. 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(3-methoxyphenyl)ethan-1-one (1), C16H14N4O3S, 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(4-methoxyphenyl)ethan-1-one (2), C16H14N4O3S, 2-[(9-acetyl-9H ...
Lígia R. Gomes +4 more
doaj +1 more source
Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Acute Lymphoblastic Leukaemia (ALL) treatment protocols widely used thiopurine drugs as an anti-cancer agent, which over the course of time results in drug toxicity.
NAWARS MOHAMMED +2 more
doaj +1 more source
European Respiratory Journal, 2019 Pulmonary arterial hypertension (PAH) is a progressive fatal disease characterised by abnormal remodelling of pulmonary vessels, leading to increased vascular resistance and right ventricle failure.
K. Kurakula +15 more
semanticscholar +1 more source
Indonesian Biomedical Journal, 2021 BACKGROUND: Eventhough 6-Mercaptopurine act as a major drug for rheumatoid arthritis (RA) treatment, however, its toxicity become a limitation. Therefore, this current study investigated whether 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG ...
Nurul Syuhada Nordin +4 more
doaj +1 more source
Life Sciences, Medicine and BiomedicineInflammatory arthritis is a chronic autoimmune disorder characterized by joint inflammation and pain, often requiring effective immunosuppressive treatment. In a rat model of inflammatory arthritis, the anti-immunosuppressive effects of 6-mercaptopurine
Che Ku Dahlan-Daud +4 more
doaj +1 more source
مجلة جامعة دمشق للعلوم الطبية, 2021 Background and Aims: NUDT15 genetic polymorphism is known to be associated with frequent hematopoietic toxicities during acute lymphoblastic leukemia (ALL) mercaptopurine therapy.
محمد ماجد محمد
doaj
Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease. [PDF]
, 2018 AimTo determine the distribution of anthropometric parameter (AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn's disease (CD).MethodsCD patients [< chronological age (CA) 21 years] were
Andrews, Howard +5 more
core +1 more source