Results 41 to 50 of about 8,386,191 (259)

Effect of preoperative thoracic duct drainage on canine kidney transplantation [PDF]

, 1996
Chronic drainage of the thoracic duct to the esophagus was developed in dogs, and its efficacy in immunomodulation was tested using kidney transplantation. Compared to 9.7 days in the control, the mean animal survival was prolonged to 9.9 days, 17.8 days,
Archimbaud JP, Atsuhito Yagihashi, Depster WJ, Dumont AE, Fischer DC, Franksson C, Franksson C, Giuseppe Carrieri, Gowans JL, Harvey J, Janossy G, Johnson HK, Julius MH, Kawai T, Koep LJ, Kohler G, Krawiec DR, Lemke H, Machieder HI, McGregor DD, McKneally M, Medawar PB, Meeker W, Mukenzie JL, Murray JE, Mysliwietz JJ, Newton WT, Oh CY, Prendergast MM, Sales HE, Satoru Todo, Schwartz R, Shibata Y, Starzl TE, Starzl TE, Starzl TE, Thomas E. Starzl, Traeger J, Williamson E PM, Woodruff M FA, Wulff JC, Wulff JC, Yoichi Funakoshi, Yuichi Iwaki   +43 more
core   +1 more source

A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

Journal of Analytical Methods in Chemistry, 2019
The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan ...
Liliya K. Shpigun, Elena Yu. Andryukhina
doaj   +1 more source

Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol

BMC Cancer, 2022
Background A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse.
Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty, Heidi Segers, Inge van der Sluis, Owen Patrick Smith, Marion Strullu, Goda Vaitkevičienė, Hilde Skuterud Wik, Mats Heyman, Kjeld Schmiegelow   +23 more
doaj   +1 more source

Polymer-Based Nanoparticles as Drug Delivery Systems for Purines of Established Importance in Medicine

Nanomaterials, 2023
Many purine derivatives are active pharmaceutical ingredients of significant importance in the therapy of autoimmune diseases, cancers, and viral infections.
Piotr Szyk, Beata Czarczynska-Goslinska, Dariusz T. Mlynarczyk, Barbara Ślusarska, Tomasz Kocki, Marta Ziegler-Borowska, Tomasz Goslinski   +6 more
doaj   +1 more source

Demonstration of enzymatic activity converting azathioprine to 6-mercaptopurine [PDF]

, 1978
The enzymatic conversion of azathioprine to 6-mercaptopurine was detected at pH 6.5 with rat liver supernatants, although the non-enzymatic reaction predominated at pH 7.0 and 7.5. Glutathione S-transferase may catalize this conversion. Activities of the
Hobara, Norio, Nagashima, Hideo, Watanabe, Akiharu   +2 more
core   +1 more source

Use of allopurinol to reduce hepatotoxicity from 6-mercaptopurine (6-MP) in patients with acute lymphoblastic leukemia (ALL)

Leukemia and Lymphoma, 2019
The overall survival of children with acute lymphoblastic leukemia (ALL) is over 90%. Much of this success comes from the daily use of 6-mercaptopurine (6-MP) during maintenance therapy [1].
Austin J. Stuckert, E. Schafer, M. Bernhardt, P. Baxter, J. Brackett   +4 more
semanticscholar   +1 more source

Serious Infections in Offspring Exposed to Tumor Necrosis Factor Inhibitors During Pregnancy: Comparison of Timing During Pregnancy and Placental Transfer Ability

Arthritis &Rheumatology, EarlyView.
Objective We evaluated serious infection risk in offspring exposed to tumor necrosis factor inhibitors (TNFi) in utero, separated by TNFi timing and placental transfer ability. Methods Using MarketScan (2011–2021), we identified offspring born to mothers with chronic inflammatory diseases.
Leah K. Flatman, Sasha Bernatsky, Yvan St‐Pierre, Marie‐Eve Beauchamp, Isabelle Malhamé, Anick Bérard, Évelyne Vinet   +6 more
wiley   +1 more source

Azathioprine-Induced Peripheral T Cell Apoptosis And Drug Response In Patients With Crohn’s Disease [PDF]

, 2011
Background and Aim: the long time interval for a trial of thioupurine therapy and the potential side effects in spite of the proven efficacy, do not encourage their use as early therapeutic option in Crohn’s Disease (CD).
Cossu, Andrea
core  

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]

, 2015
Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju, Chemaitilly, Wassim, Frase, Sharon, Green, Daniel M, Janke, Laura, Lynch, John, Morgan, Jessica A, Opferman, Joseph T, Panetta, John C, Schuetz, John D, Wang, Yao, Zheng, Jie   +11 more
core   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source