Results 91 to 100 of about 9,551,377 (187)
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Desenvolvimento de miliesferas poliméricas de Quitosana/Alginato contendo [6]-shogaol [PDF]
Chitosan and sodium alginate are used in the production of modified drug-release millispheres. This technology can be used as an alternative to improve the therapeutic efficacy of active substances, such as [6]-shogaol, a natural product found in ginger ...
Passos, Mariana da Cruz
core
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.Diabetes mellitus causes significant damage to the male reproductive system. Sirt1/Nrf2/HO‐1 signaling pathway acts as a line of defense against ROS in reproductive organs. In STZ‐induced diabetic rats, the proapoptotic Bax protein expression was found to be elevated, whereas the antiapoptotic Bcl‐2 protein expression was reduced.
Edanur Güler Ekmen +3 more
wiley +1 more source
Pharmacological studies on ginger. V Pharmacological comparison between (6)-shogaol and capsaicin.
Folia Pharmacologica Japonica, 1986 Pharmacological actions of (6)-shogaol and capsaicin were studied. Both (6)-shogaol (0.5 mg/kg, i.v.) and capsaicin (0.1 mg/kg, i.v.) caused a triad such as a rapid fall in blood pressure, bradycardia and aponea in rats. Both drugs-induced marked pressor responses in blood pressure, which occurred after the rapid fall, were markedly reduced by a spinal
M, Suekawa +5 more
openaire +3 more sources
[6]-Shogaol Induces Ca2+ Signals by Activating the TRPV1 Channels in the Rat Insulinoma INS-1E Cells [PDF]
, 2014 Context [6]-shogaol is a vanilloid compound present in steamed ginger (Zingiber officinale), a commonly used spice. Pancreatic beta-cells respond to nutrients like glucose, amino acids and fatty acids, by an increase in the cytoplasmic free Ca2 ...
Islam, Md. Shahidul +3 more
core +1 more source
Confirmation of the action of 6-shogaol on breast cancer spheroids.
, 2015 (A): Flow cytometric analysis of CD44+ /CD24- expression in untreated spheres (right upper panel) and spheres treated with 40 μM 6-shogaol for 18 hours (right lower panel).
Anasuya Ray (793851) +2 more
core +1 more source
Journal of Pharmacological Sciences, 2008 The effects of goshuyuto and chotosan, traditional Japanese medicines, on collagen-induced platelet aggregation were examined using guinea-pig blood. Goshuyuto at the concentration of 1,000 μg/mL inhibited collagen-induced platelet hyper-aggregation to ...
Tomoko Hibino +5 more
doaj +1 more source
Analytical Cellular Pathology, 2019 Aim. This study is aimed at investigating the effect of Shogaol, a phenolic constituent of ginger, on dextran sodium sulfate- (DSS-) induced ulcerative colitis (UC) in mice in comparison with 6-thioguanine (6-TG), an immune-suppressant chemotherapeutic ...
Snur M. A. Hassan, Ali Hussein Hassan
doaj +1 more source
Effects of 6-shogaol on ER stress signaling proteins.
, 2012 The cells were treated with or without 20 µM 6-shogaol for 1, 3, 6, 12, and 24 h. Total cellular extracts were prepared and subjected to Western blot analysis using antibodies against PARP, caspase-3 and ER stress-related molecular chaperones (A) and ER ...
Yong-Bo Peng (153732) +10 more
core +1 more source
6-Shogaol-Rich Extract from Ginger Up-Regulates the Antioxidant Defense Systems in Cells and Mice
Molecules, 2012 The rhizome of ginger (<em>Zingiber officinale</em> Roscoe) is known to have several bioactive compounds including gingerols and shogaols which possess beneficial health properties such as anti-inflammatory and chemopreventive effects.
Mira Jun +3 more
doaj +1 more source