Results 151 to 160 of about 37,816 (179)
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Scandinavian Journal of Medicine & Science in Sports, 2016
Muscle damage caused through impacts in rugby union is known to increase oxidative stress and inflammation. Pterins have been used clinically as markers of oxidative stress, inflammation, and neurotransmitter synthesis. This study investigates the release of myoglobin from muscle tissue due to force‐related impacts and how it is related to the ...
A. Lindsay +6 more
semanticscholar +3 more sources
Muscle damage caused through impacts in rugby union is known to increase oxidative stress and inflammation. Pterins have been used clinically as markers of oxidative stress, inflammation, and neurotransmitter synthesis. This study investigates the release of myoglobin from muscle tissue due to force‐related impacts and how it is related to the ...
A. Lindsay +6 more
semanticscholar +3 more sources
Effects of neopterin and 7,8‐dihydroneopterin on hypoxia‐induced renal erythropoietin production
European Journal of Haematology, 1999Abstract: Activation of the human cellular immune system is associated with greatly increased formation of the pteridines neopterin and 7,8‐dihydroneopterin. It has been postulated that pteridines play a role in the pathogenesis of the anaemia of inflammation.
H. Pagel +4 more
semanticscholar +3 more sources
Dissociation of neopterin and 7,8-dihydroneopterin from plasma components before HPLC analysis.
Journal of Chromatography B, 2008Measurement of plasma neopterin by HPLC with fluorescence detection is used clinically as a marker of immune cell activation in the management of a number of disease pathologies. HPLC analysis of neopterin requires the acidic removal of plasma proteins but we have found that 7,8-dihydroneopterin is oxidised to neopterin with varying yield.
E. Flavall +3 more
semanticscholar +3 more sources
Free Radical Research, 2001
Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). The purpose of this cellular response is undetermined but in vitro experiments suggests 7,8-NP is an antioxidant. We have found 7,8-NP can protect monocyte-like U937 cells from oxidative damage.
S. Gieseg +3 more
semanticscholar +3 more sources
Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). The purpose of this cellular response is undetermined but in vitro experiments suggests 7,8-NP is an antioxidant. We have found 7,8-NP can protect monocyte-like U937 cells from oxidative damage.
S. Gieseg +3 more
semanticscholar +3 more sources
Photodimerization of 7,8‐Dihydroneopterin in Aqueous Solution Under UV‐A Irradiation
Photochemistry and Photobiology, 2011Abstract7,8‐Dihydroneopterin (H2Nep) is secreted during the oxidative burst of stimulated macrophages. The photochemistry of H2Nep was investigated in neutral aqueous solutions exposed to UV‐A radiation (320–400 nm) at room temperature. The kinetics were followed by UV/Vis spectrophotometry and HPLC, whereas the photoproducts were analyzed by ...
M. Vignoni +3 more
semanticscholar +3 more sources
Free Radical Research, 2002
Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic lesions. Oxidatively modified LDL particles exert chemotactic properties on macrophages, and the uncontrolled uptake of modified LDL by macrophages leads to the formation of lipid-loaded foam cells, a hallmark of early stage ...
I. Herpfer +5 more
semanticscholar +3 more sources
Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic lesions. Oxidatively modified LDL particles exert chemotactic properties on macrophages, and the uncontrolled uptake of modified LDL by macrophages leads to the formation of lipid-loaded foam cells, a hallmark of early stage ...
I. Herpfer +5 more
semanticscholar +3 more sources
Mechanisms of 7,8-dihydroneopterin protection of macrophages from cytotoxicity [PDF]
, 2013 Gamma-interferon stimulates human macrophages to produce of 7,8-dihydroneopterin (7,8-NP). 7,8-NP and its oxidation product neopterin are excellent inflammatory markers for a variety of chronic conditions, including atherosclerosis. The biological significance of 7,8-NP in atherosclerosis is not fully understood, but 7,8-NP has been shown to protect ...
Shchepetkina, Anastasia
openaire +4 more sources
trans-Activation of the HIV Type 1 Promoter by 7,8-Dihydroneopterin in Vitro
AIDS Research and Human Retroviruses, 1997Infection with human immunodeficiency virus type 1 and 2 is associated with elevated concentrations of neopterin, released in large quantities by human macrophages on stimulation with interferon gamma. Evidence has suggested a potential role of neopterin derivatives in oxygen radical-mediated processes.
G. Baier‐Bitterlich +8 more
semanticscholar +3 more sources
Journal of Molecular Biology, 2004
Dihydroneopterin aldolase (DHNA) catalyses a retroaldol reaction yielding 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin, tetrahydrofolate. The enzyme is a potential target for antimicrobial and anti-parasite chemotherapy. A gene specifying a dihydroneopterin aldolase from Arabidopsis thaliana was expressed in a recombinant ...
S. Bauer +5 more
semanticscholar +4 more sources
Dihydroneopterin aldolase (DHNA) catalyses a retroaldol reaction yielding 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin, tetrahydrofolate. The enzyme is a potential target for antimicrobial and anti-parasite chemotherapy. A gene specifying a dihydroneopterin aldolase from Arabidopsis thaliana was expressed in a recombinant ...
S. Bauer +5 more
semanticscholar +4 more sources
Medical Microbiology and Immunology, 2007
Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response.
O. Bratslavska +4 more
semanticscholar +3 more sources
Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response.
O. Bratslavska +4 more
semanticscholar +3 more sources