Results 151 to 160 of about 37,102 (171)
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Free Radical Research, 2001
Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). The purpose of this cellular response is undetermined but in vitro experiments suggests 7,8-NP is an antioxidant. We have found 7,8-NP can protect monocyte-like U937 cells from oxidative damage.
Chris Rait +3 more
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Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). The purpose of this cellular response is undetermined but in vitro experiments suggests 7,8-NP is an antioxidant. We have found 7,8-NP can protect monocyte-like U937 cells from oxidative damage.
Chris Rait +3 more
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trans-Activation of the HIV Type 1 Promoter by 7,8-Dihydroneopterinin Vitro
AIDS Research and Human Retroviruses, 1997Infection with human immunodeficiency virus type 1 and 2 is associated with elevated concentrations of neopterin, released in large quantities by human macrophages on stimulation with interferon gamma. Evidence has suggested a potential role of neopterin derivatives in oxygen radical-mediated processes.
Ernst R. Werner +8 more
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Photodimerization of 7,8‐Dihydroneopterin in Aqueous Solution Under UV‐A Irradiation
Photochemistry and Photobiology, 2010Abstract7,8‐Dihydroneopterin (H2Nep) is secreted during the oxidative burst of stimulated macrophages. The photochemistry of H2Nep was investigated in neutral aqueous solutions exposed to UV‐A radiation (320–400 nm) at room temperature. The kinetics were followed by UV/Vis spectrophotometry and HPLC, whereas the photoproducts were analyzed by ...
Andrés H. Thomas +3 more
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Medical Microbiology and Immunology, 2006
Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response.
Agris Martinsons +4 more
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Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response.
Agris Martinsons +4 more
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Biochemical Pharmacology, 1998
Activated cell-mediated immunity, associated for example with HIV infection, is accompanied by elevated concentrations of neopterin and 7,8-dihydroneopterin. Recent data have indicated a role of neopterin derivatives in virus activation and apoptotic cell death, processes likely to involve the action of oxygen free radicals.
Bernhard Widner +4 more
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Activated cell-mediated immunity, associated for example with HIV infection, is accompanied by elevated concentrations of neopterin and 7,8-dihydroneopterin. Recent data have indicated a role of neopterin derivatives in virus activation and apoptotic cell death, processes likely to involve the action of oxygen free radicals.
Bernhard Widner +4 more
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Synthesis of enzymatically active D-7,8-dihydroneopterin-3′-triphosphate
Biochemical and Biophysical Research Communications, 1988The first chemical synthesis of D-neopterin-3'-triphosphate and D-7,8-dihydroneopterin-3'-triphosphate is described. D-neopterin-3'-monophosphate was first 1'-2'-0-formylated with anhydrous formic acid, then activated with 1,1'-carbonyldiimidazole and phosphorylated with n-tributyl-ammonium pyrophosphate. The yield of 3'-NTP was 24%.
U. Redweik +4 more
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Free radical research, 1995
Neopterin and its reduced form, 7,8 dihydroneopterin are pteridines released from macrophages and monocytes when stimulated with interferon gamma in vivo.
S. Gieseg +3 more
semanticscholar +1 more source
Neopterin and its reduced form, 7,8 dihydroneopterin are pteridines released from macrophages and monocytes when stimulated with interferon gamma in vivo.
S. Gieseg +3 more
semanticscholar +1 more source
Generation of carbon monoxide and iron from hemeproteins in the presence of 7,8-dihydroneopterin
Biochimica et Biophysica Acta (BBA) - General Subjects, 20027,8-Dihydroneopterin and neopterin are secreted by human and primate macrophages after activation by interferon-gamma in a ratio of 2:1. 7,8-Dihydroneopterin is known to suppress radical-mediated processes, but it is also able in the presence of iron ions to generate superoxide radical anion and hydroxyl radicals from molecular oxygen.
Erwin Tafeit +4 more
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7,8-Dihydroneopterin and its effect on the formation of foam cells.
2015Atherosclerosis (Heart Disease) is an inflammatory disease caused by the formation of plaque within the arterial wall. In response to inflammation, monocytes enter the artery wall, differentiate into macrophages and take up altered low-density-lipoprotein (such as oxidised-LDL). This oxLDL is taken up into the phagocytotic macrophages via the action of
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2006
Any lipoproteins and cells present in the inflammatory environment of atherosclerotic plaques are likely to be exposed to high levels of oxidative stress. As 7,8-dihydroneopterin (7,8-NP) is synthesized by interferon-γ (IFN-γ)-activated macrophages, this pteridine is also thought to exist at sites of inflammation.
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Any lipoproteins and cells present in the inflammatory environment of atherosclerotic plaques are likely to be exposed to high levels of oxidative stress. As 7,8-dihydroneopterin (7,8-NP) is synthesized by interferon-γ (IFN-γ)-activated macrophages, this pteridine is also thought to exist at sites of inflammation.
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