Results 161 to 170 of about 37,102 (171)

Neopterin and 7,8-Dihydroneopterin-Induced Signal Transduction Cascades in Cell Lines

2002
Stimulation of monocytes/macrophages with IFN-g, derived from activated T cells, results in the release of elevated concentrations of neopterin and 7,8-dihydroneopterin by activation of GTP cyclohydrolase I (1,2). In patients, he production of neopterin hereby closely correlates with IFN-g concentrations and the activation of cell mediated immunity (3).
Christiane Enzinger, Barbara Wirleitner, Dietmar Fuchs, Günther Böck, Gabriele Baier-Bitterlich, Christina Lutz, Harald Niederegger   +6 more
openaire   +2 more sources

Role of 7,8-dihydroneopterin in T-cell apoptosis and HTLV-1 transcription in vitro.

Oncogene, 1997
Adult T-cell leukemia is associated with high levels of neopterin, released in large amounts from human macrophages upon stimulation with interferon-gamma. Recent data suggested a potential role of neopterin-derivatives in oxygen radical-mediated processes, and evidence accumulates that oxidative stress is involved in the pathogenesis of viral diseases.
G, Baier-Bitterlich, G, Baier, D, Fuchs, G, Böck, A, Hausen, G, Utermann, M, Pavelka, H, Wachter   +7 more
openaire   +1 more source

Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages.

International Journal of Biochemistry and Cell Biology, 2017
Anastasia A Shchepetkina, B. Hock, Allison L. Miller, M. Kennedy, S. Gieseg   +4 more
semanticscholar   +1 more source

Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from staphylococcus aureus

Nature Structural Biology, 1998
M. Hennig, A. D'arcy, I. Hampele, M. Page, C. Oefner, G. Dale   +5 more
semanticscholar   +1 more source

Increased 7,8-dihydroneopterin and reduced methyl-group metabolism in HIV-1 infection

The Lancet, 1990
Gilbert Reibnegger, Dietmar Fuchs, Helmut Wachter, Ernst R. Werner   +3 more
openaire   +3 more sources

7,8-dihydroneopterin inhibition of oxidised low density lipoprotein-induced cellular death

2003
The death of monocyte and macrophage cells in the atherosclerotic plaque is thought to be due principally to the toxicity of oxidised LDL (oxLDL). This makes an important contribution to the development of the lipid core of advanced plaque and also to the overall stability of the plaque.
openaire   +3 more sources

Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class.

Journal of Molecular Biology, 2004
S. Bauer, A. Schott, V. Illarionova, A. Bacher, R. Huber, M. Fischer   +5 more
semanticscholar   +1 more source

Induction of apoptosis in human blood T cells by 7,8-dihydroneopterin: the difference between healthy controls and patients with systemic lupus erythematosus.

Clinical Immunology, 2003
B. Wirleitner, G. Obermoser, G. Böck, G. Neurauter, H. Schennach, N. Sepp, D. Fuchs   +6 more
semanticscholar   +1 more source

Induction of apoptosis by 7,8-dihydroneopterin: involvement of radical formation.

Immunobiology, 2001
B. Wirleitner, R. Czaputa, K. Oettl, G. Böck, B. Widner, G. Reibnegger, G. Baier, D. Fuchs, G. Baier‐Bitterlich   +8 more
semanticscholar   +1 more source

Inflammation marker 7,8-dihydroneopterin induces apoptosis of neurons and glial cells: a potential contribution to neurodegenerative processes.

Immunobiology, 2000
C. Speth, G. Stöckl, D. Fuchs, B. Wirleitner, B. Widner, R. Würzner, I. Mohsenipour, C. Lass‐Flörl, M. Dierich   +8 more
semanticscholar   +1 more source