Results 161 to 170 of about 37,816 (179)

Synthesis of enzymatically active D-7,8-dihydroneopterin-3′-triphosphate

Biochemical and Biophysical Research Communications, 1988
The first chemical synthesis of D-neopterin-3'-triphosphate and D-7,8-dihydroneopterin-3'-triphosphate is described. D-neopterin-3'-monophosphate was first 1'-2'-0-formylated with anhydrous formic acid, then activated with 1,1'-carbonyldiimidazole and phosphorylated with n-tributyl-ammonium pyrophosphate. The yield of 3'-NTP was 24%.
B, Zagalak, F, Neuheiser, U, Redweik, R, Bosshard, W, Leimbacher   +4 more
openaire   +2 more sources

Generation of carbon monoxide and iron from hemeproteins in the presence of 7,8-dihydroneopterin

Biochimica et Biophysica Acta (BBA) - General Subjects, 2002
7,8-Dihydroneopterin and neopterin are secreted by human and primate macrophages after activation by interferon-gamma in a ratio of 2:1. 7,8-Dihydroneopterin is known to suppress radical-mediated processes, but it is also able in the presence of iron ions to generate superoxide radical anion and hydroxyl radicals from molecular oxygen.
Renate, Horejsi, Christiane, Jung, Reinhard, Möller, Erwin, Tafeit, Gilbert, Reibnegger   +4 more
openaire   +2 more sources

Neopterin and 7,8-Dihydroneopterin-Induced Signal Transduction Cascades in Cell Lines

2002
Stimulation of monocytes/macrophages with IFN-g, derived from activated T cells, results in the release of elevated concentrations of neopterin and 7,8-dihydroneopterin by activation of GTP cyclohydrolase I (1,2). In patients, he production of neopterin hereby closely correlates with IFN-g concentrations and the activation of cell mediated immunity (3).
Christiane Enzinger, Barbara Wirleitner, Christina Lutz, Harald Niederegger, Günther Böck, Gabriele Baier-Bitterlich, Dietmar Fuchs   +6 more
openaire   +1 more source

Foam cell formation but not oxLDL cytotoxicity is inhibited by CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin.

International Journal of Biochemistry and Cell Biology, 2021
N. Ghodsian, Anthony Yeandle, S. Gieseg
semanticscholar   +1 more source

7,8-Dihydroneopterin and its effect on the formation of foam cells.

2015
Atherosclerosis (Heart Disease) is an inflammatory disease caused by the formation of plaque within the arterial wall. In response to inflammation, monocytes enter the artery wall, differentiate into macrophages and take up altered low-density-lipoprotein (such as oxidised-LDL). This oxLDL is taken up into the phagocytotic macrophages via the action of
openaire   +2 more sources

Biopterin

Neurochemical Research, 1979
An enzyme that catalyzes the conversion of 2-amino-6-(5'-triphosphoribosyl)amino-5- or 6-formamido-6-hydroxypyrimidine, but not of guanosine triphosphate, to quinonoid 6-(D-erythro-1'-2'-3'-trihydroxypropyl)dihydropterin triphosphate and formic acid has been purified to homogeneity from some mammalian brain and liver. The enzyme of a single strand is a
E M, Gál, M R, Dawson, D T, Dudley, A D, Sherman   +3 more
openaire   +2 more sources

Regulation of the CD36 scavenger receptor by the antioxidant 7,8-dihydroneopterin.

2017
OxLDL uptake via the CD36 scavenger receptor leads to foam cell formation and is at the core of the development of atherosclerosis. One potential protective mechanism against this process involves the human macrophage derived anti-oxidant 7,8-dihydroneopterin (7,8-NP) down regulating CD36.
openaire   +2 more sources

7,8-dihydroneopterin inhibition of oxidised low density lipoprotein-induced cellular death

2003
The death of monocyte and macrophage cells in the atherosclerotic plaque is thought to be due principally to the toxicity of oxidised LDL (oxLDL). This makes an important contribution to the development of the lipid core of advanced plaque and also to the overall stability of the plaque.
openaire   +2 more sources

Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages.

International Journal of Biochemistry and Cell Biology, 2017
Anastasia A Shchepetkina, B. Hock, Allison L. Miller, M. Kennedy, S. Gieseg   +4 more
semanticscholar   +1 more source

Mechanism of 7,8-dihydroneopterin to downregulate CD36 scavenger receptor and foam cell formation.

2019
Atherosclerosis is a disorder that involves the build-up of plaque in medium and large arteries. Atherosclerotic plaques are made from a range of cellular and extracellular components including lipid-filled immune cells, smooth muscle cells (SMC), T-cells and fibroblasts.
openaire   +2 more sources