Results 151 to 160 of about 26,693 (166)
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Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from staphylococcus aureus
Nature Structural Biology, 1998Dihydroneopterin aldolase catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin during the de novo synthesis of folk acid from guanosine triphosphate. The gene encoding the dihydroneopterin aldolase from S. aureus has been cloned, sequenced and expressed in Escherichia coli.
Michael Hennig +5 more
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Neopterin and 7,8-Dihydroneopterin-Induced Signal Transduction Cascades in Cell Lines
2002Stimulation of monocytes/macrophages with IFN-g, derived from activated T cells, results in the release of elevated concentrations of neopterin and 7,8-dihydroneopterin by activation of GTP cyclohydrolase I (1,2). In patients, he production of neopterin hereby closely correlates with IFN-g concentrations and the activation of cell mediated immunity (3).
Christiane Enzinger +6 more
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Oral Diseases
AbstractObjectiveDetermine the saliva and serum levels of neopterin (NP) and 7,8‐dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.Materials and MethodsTwenty‐three patients with stage III/grade B periodontitis and 23 periodontally healthy individuals were included ...
Emrah Turkmen +8 more
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AbstractObjectiveDetermine the saliva and serum levels of neopterin (NP) and 7,8‐dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.Materials and MethodsTwenty‐three patients with stage III/grade B periodontitis and 23 periodontally healthy individuals were included ...
Emrah Turkmen +8 more
openaire +2 more sources
Free Radical Research, 2001
Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). The purpose of this cellular response is undetermined but in vitro experiments suggests 7,8-NP is an antioxidant. We have found 7,8-NP can protect monocyte-like U937 cells from oxidative damage.
Gieseg, S. P. +3 more
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Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). The purpose of this cellular response is undetermined but in vitro experiments suggests 7,8-NP is an antioxidant. We have found 7,8-NP can protect monocyte-like U937 cells from oxidative damage.
Gieseg, S. P. +3 more
openaire +3 more sources
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1996
Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin concentrations thus inversely correlate with absolute CD4+ T-cell numbers and strongly predict progression of disease from ...
G, Baier-Bitterlich +2 more
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Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin concentrations thus inversely correlate with absolute CD4+ T-cell numbers and strongly predict progression of disease from ...
G, Baier-Bitterlich +2 more
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Role of 7,8-dihydroneopterin in T-cell apoptosis and HTLV-1 transcription in vitro.
Oncogene, 1997Adult T-cell leukemia is associated with high levels of neopterin, released in large amounts from human macrophages upon stimulation with interferon-gamma. Recent data suggested a potential role of neopterin-derivatives in oxygen radical-mediated processes, and evidence accumulates that oxidative stress is involved in the pathogenesis of viral diseases.
G, Baier-Bitterlich +7 more
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Increased 7,8-dihydroneopterin and reduced methyl-group metabolism in HIV-1 infection
The Lancet, 1990D, Fuchs +3 more
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7,8 dihydroneopterin can protect cells from free radical mediated damage
Free Radical Biology and Medicine, 1998Gieseg, Steven +4 more
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