Results 91 to 100 of about 13,198 (194)

Assays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patients[S]

Journal of Lipid Research, 2013
Smith-Lemli-Opitz syndrome (SLOS) is caused by mutations in the gene encoding 3β-hydroxysterol-Δ7-reductase and as a result of this defect, 7-dehydrocholesterol (7-DHC) and 8-dehydrocholesterol (8-DHC) accumulate in the fluids and tissues of patients ...
Wei Liu, Libin Xu, Connor R. Lamberson, Louise S. Merkens, Robert D. Steiner, Ellen R. Elias, Dorothea Haas, Ned A. Porter   +7 more
doaj   +1 more source

The Photochemical Dehydrogenation of Ergosterol and 7-Dehydrocholesterol [PDF]

Bulletin of the Chemical Society of Japan, 1939
Abstract Ergopinacone and 7-dehydrocholesterol-pinacone have been prepared by two different methods, viz., the boiling method and the carbon dioxide method. The products obtained by the two methods as well as diacetates and dibenzoates derived from them have been compared.
openaire   +1 more source

ALDOA‐Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer

Advanced Science, Volume 13, Issue 6, 30 January 2026.
ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang, Kezhang He, Bowen Wang, Wei Zhou, Ying Zhang, Tianhua Ma, Sheng Ding   +6 more
wiley   +1 more source

DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model

Neurobiology of Disease, 2012
Smith–Lemli–Opitz syndrome (SLOS) is an inborn error of metabolism caused by defective cholesterol biosynthesis. Mutations within the gene encoding 7-dehydrocholesterol reductase (DHCR7), the last enzyme in the pathway, lead to the accumulation of 7 ...
Libin Xu, Karoly Mirnics, Aaron B. Bowman, Wei Liu, Jennifer Da, Ned A. Porter, Zeljka Korade   +6 more
doaj   +1 more source

Smith Lemli Opitz syndrome: a case report

Khyber Medical University Journal, 2015
INTRODUCTION; Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive genetic condition caused by deficiency of the enzyme 7-dehydrocholesterol-delta 7-reductase.
saima ali, Saffiullah Khalil, Liaqat Ali
doaj  

Measurement of 3 beta-hydroxysteroid delta 7-reductase activity in cultured skin fibroblasts utilizing ergosterol as a substrate: a new method for the diagnosis of the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 1996
A new sensitive and specific method for the evaluation of 3 beta-hydroxysteroid delta 7-reductase activity, the defective enzyme in the Smith-Lemli-Opitz (SLO) syndrome, is described.
M Honda, G S Tint, A Honda, A K Batta, T S Chen, S Shefer, G Salen   +6 more
doaj   +1 more source

The control of calcium metabolism by parathyroid hormone, calcitonin and vitamin D [PDF]

Advances in analysis of chemistry and physiology of parathyroid hormone, calcitonin, and Vitamin D are described along with development of techniques in radioassay methods.
Potts, J. T., Jr.
core   +1 more source

Sterolomics: State of the Art, Developments, Limitations and Challenges [PDF]

, 2017
Sterolomics can be thought of as the quantitative determination of the entire complement of molecules based on the cyclopentanoperhydrophenanthrene skeleton in a system. Mass spectrometry is the dominant analytical technology employed. In this article we
Abdel-Khalik, Clayton, Cobice, Dzeletovic, Fahy, Griffiths, Griffiths, Griffiths, Griffiths, Jones, Karu, Liebisch, Lütjohann, McDonald, Saeed, Schroepfer, Sempos, William J. Griffiths, Wudy, Xu, Xu, Yuqin Wang   +21 more
core   +1 more source

Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome[S]

Journal of Lipid Research, 2010
Smith-Lemli-Opitz syndrome (SLOS) is a metabolic and developmental disorder caused by mutations in the gene encoding the enzyme 7-dehydrocholesterol reductase (Dhcr7).
Zeljka Korade, Libin Xu, Richard Shelton, Ned A. Porter   +3 more
doaj   +1 more source

Solar ultraviolet-B radiation and vitamin D: a cross-sectional population-based study using data from the 2007 to 2009 Canadian Health Measures Survey [PDF]

, 2012
Background: Exposure to solar ultraviolet-B (UV-B) radiation is a major source of vitamin D3. Chemistry climate models project decreases in ground-level solar erythemal UV over the current century.
A Gozdzik, A Gozdzik, AE Millen, AF Bais, AR Webb, AR Webb, B Day, C Gagnon, D Rucker, DP Dee, E Giovannucci, E Liu, Ellie Farahani, EM Hume, FM Moy, H Sahota, Institute of Medicine, J Ahn, J Chan, J Wortsman, JA MacLaughlin, JA MacLaughlin, Jamie A Greenfield, Julia A Knight, K Langlois, LS Greene-Finestone, M Holick, M Tremblay, MF Holick, MF Holick, MI Hegglin, N Binkley, Norman A McFarlane, O Engelsen, Philip S Park, R Baraké, R Scragg, R Vieth, Reinhold Vieth, S Bryan, S Giroux, S Madronich, S Sloka, SJ Whiting, SR Cole, Suneil Malik, TC Chen, TG Shepherd, Theodore G Shepherd, TL Clemens, VE Fioletov   +50 more
core   +2 more sources