Results 131 to 140 of about 76,183,421 (152)

Substance Use Disorder Following Consumption of a Novel Synthetic 7-Hydroxymitragynine Product

Journal of Addiction Medicine
Background: Products containing semi-synthetic 7-hydroxymitragynine (7-OH), a potent mu-opioid receptor (MOR) agonist, have proliferated in the United States. In kratom leaf, trace amounts of 7-OH are formed by spontaneous oxidization of kratom’s primary alkaloid, mitragynine.
Brandon Reif, Alek Adkins, Edward W. Boyer, Siva Rama Raju Kanumuri, Abhisheak Sharma, Kirsten E. Smith   +5 more
openaire   +2 more sources

Abuse liability and therapeutic potential of theMitragyna speciosa(kratom) alkaloids mitragynine and 7‐hydroxymitragynine

Addiction Biology, 2018
AbstractKratom, derived from the plantMitragyna speciosa,is receiving increased attention as an alternative to traditional opiates and as a replacement therapy for opiate dependence. Mitragynine (MG) and 7‐hydroxymitragynine (7‐HMG) are major psychoactive constituents of kratom. While MG and 7‐HMG share behavioral and analgesic properties with morphine,
Scott E. Hemby, Scot McIntosh, Francisco Leon, Stephen J. Cutler, Christopher R. McCurdy   +4 more
openaire   +2 more sources

Evaluation of In Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Properties of Mitragynine, 7-Hydroxymitragynine, and Mitraphylline

Planta Medica, 2014
Mitragyna speciosa (kratom) is a popular herb in Southeast Asia, which is traditionally used to treat withdrawal symptoms associated with opiate addiction. Mitragynine, 7-hydroxymitragynine, and mitraphylline are reported to be the central nervous system active alkaloids which bind to the opiate receptors.
Vamshi K, Manda, Bharathi, Avula, Zulfiqar, Ali, Ikhlas A, Khan, Larry A, Walker, Shabana I, Khan   +5 more
openaire   +2 more sources

Buprenorphine for the Management of 7-Hydroxymitragynine (7-OH) Use: A Retrospective Case Series

Journal of Addiction Medicine
Background: Kratom ( Mitragyna speciosa ) is increasingly used in the United States as a dietary supplement for pain, mood regulation, and opioid withdrawal.
Emma Fenske, Beth Williams, Laurel Hallock-Koppelman, Bradley M. Buchheit   +3 more
openaire   +1 more source

In Vitro and In Vivo Pharmacokinetic Characterization of 7-Hydroxymitragynine, an Active Metabolite of Mitragynine, in Sprague-Dawley Rats

European Journal of Drug Metabolism and Pharmacokinetics
Kratom, a Southeast Asian tree, has been researched for its potential as a therapeutic for substance use disorders. The most abundant alkaloid in kratom, mitragynine, is being investigated individually for opioid use disorder. However, the active metabolite of mitragynine,7-hydroxymitragynine (7-HMG) has raised concerns because of its high binding ...
Yi-Hua Chiang, Siva Rama Raju Kanumuri, Michelle A. Kuntz, Alexandria S. Senetra, Erin C. Berthold, Shyam H. Kamble, Sushobhan Mukhopadhyay, Aidan J. Hampson, Christopher R. McCurdy, Abhisheak Sharma   +9 more
openaire   +2 more sources

Determination of ADME properties of mitragynine, 7-hydroxymitragynine, and mitraphylline

Planta Medica, 2014
VK Manda, B Avula, Z Ali, IA Khan, LA Walker, SI Khan   +5 more
openaire   +1 more source

7-Hydroxymitragynine: Not Your Garden Variety Kratom

American Journal of Forensic Medicine & Pathology
Donna M. Papsun, William Schroeder, Justin Brower, Alex Krotulski, Kayla Ellefsen   +4 more
openaire   +1 more source

Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats

Journal of Pharmacology and Experimental Therapeutics, 2021
Marco Mottinelli, Christopher R McCurdy, Francisco León   +2 more
exaly  

Involvement of μ-Opioid Receptors in Antinociception and Inhibition of Gastrointestinal Transit Induced by 7-Hydroxymitragynine, Isolated From Thai Herbal Medicine Mitragyna speciosa

European Journal of Pharmacology, 2006
Kenjiro Matsumoto, Kimihito Tashima, Hiromitsu Takayama   +2 more
exaly  

Semi-synthetic products based on 7-hydroxymitragynine: a public health emergency

Medical Research Archives
Franco Posa, Camilla Trussardi, Matteo Posa, Victoria Colmenares Pulido, Vanessa Vener   +4 more
openaire   +1 more source