Results 131 to 140 of about 824 (158)

Asymmetric Total Syntheses of Mitragynine, Speciogynine, and 7-Hydroxymitragynine

Chemical and Pharmaceutical Bulletin, 2022
A number of alkaloids found in Mitragyna species belonging to the Rubiaceae family have been shown to have potent biological activity such as analgesic properties. Here, we report the asymmetric total syntheses of mitragynine, speciogynine, and 7-hydroxymitragynine, which are classified as corynantheine-type monoterpenoid indole alkaloids, isolated ...
Jukiya Sakamoto, Hayato Ishikawa
exaly   +3 more sources

Mitragynine and 7-hydroxymitragynine: Bidirectional effects on breathing in rats

Journal of Pharmacology and Experimental Therapeutics
Abstract The use of kratom as an alternative to conventional opioids has surged, driven largely by anecdotal reports of its efficacy for pain relief and opioid withdrawal management. The growing prevalence of kratom products enriched with 7-hydroxymitragynine (7-HMG), an active metabolite of mitragynine (MG), necessitates evaluating the
Sushobhan Mukhopadhyay, Christopher R Mccurdy, Lance R McMahon   +2 more
exaly   +4 more sources

Screening and Identification of Mitragynine and 7-Hydroxymitragynine in Human Urine by LC-MS/MS [PDF]

Chromatography (Basel), 2015
Kratom is a tree planted in Southeast Asia, including Thailand, Malaysia, Myanmar (Burma) and elsewhere in the region. A long history of usage and abuse of kratom has led to the classification of kratom as a controlled substance in its native Thailand and other Southeast Asian countries.
Hanzhuo Fu
exaly   +2 more sources

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Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa

Life Sciences, 2005
7-Hydroxymitragynine is a potent opioid analgesic alkaloid isolated from the Thai medicinal herb Mitragyna speciosa. In the present study, we investigated the opioid receptor subtype responsible for the analgesic effect of this compound. In addition, we tested whether development of tolerance, cross-tolerance to morphine and naloxone-induced withdrawal
Kenjiro Matsumoto, Syunji Horie, Hayato Ishikawa   +2 more
exaly   +3 more sources

Postmortem distribution of mitragynine and 7-hydroxymitragynine in 51 cases

Journal of Analytical Toxicology
Abstract The prevalence of mitragynine (kratom) in forensic toxicology casework has steadily increased over time. Readily available and currently legal, mitragynine is widely used for its stimulant and, depending on concentration, sedative effects.
Kei A Osawa, Robert D Johnson
openaire   +2 more sources

Development, validation, and application of an LC–MS/MS method for mitragynine and 7‐hydroxymitragynine analysis in hair

Drug Testing and Analysis, 2020
AbstractThe entire scalp hair of a self‐declared Kratom consumer of 3 grams per day was acquired during an ethical committee approved study. As no values of the concentration in hair of the two Kratom alkaloids mitragynine or 7‐hydroxymitragynine were found in the literature, an already established method for the analysis of benzodiazepines/z ...
Ulf Meier, Katja Mercer‐Chalmers‐Bender, Eva Scheurer, Franz Dussy   +3 more
openaire   +3 more sources

Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa

Life Sciences, 2004
Mitragynine is an indole alkaloid isolated from the Thai medicinal plant Mitragyna speciosa. We previously reported the morphine-like action of mitragynine and its related compounds in the in vitro assays. In the present study, we investigated the opioid effects of 7-hydroxymitragynine, which is isolated as its novel constituent, on contraction of ...
Kenjiro Matsumoto, Syunji Horie, Hayato Ishikawa   +2 more
exaly   +3 more sources

De facto opioids: Characterization of novel 7-hydroxymitragynine and mitragynine pseudoindoxyl product marketing

Drug and Alcohol Dependence
Within the past year, the online sale of semi-synthetic products containing chemicals derived from mitragynine, kratom's primary alkaloid: 7-hydroxymitragynine (7-OH) and mitragynine pseudoindoxyl (MP) has emerged. Both are highly selective mu opioid receptor agonists undetectable or not present in fresh kratom leaves and may, as constituents of novel ...
Edward W Boyer, Oliver Grundmann, Katherine Hill   +2 more
exaly   +3 more sources

Abuse liability and therapeutic potential of theMitragyna speciosa(kratom) alkaloids mitragynine and 7‐hydroxymitragynine

Addiction Biology, 2018
AbstractKratom, derived from the plantMitragyna speciosa,is receiving increased attention as an alternative to traditional opiates and as a replacement therapy for opiate dependence. Mitragynine (MG) and 7‐hydroxymitragynine (7‐HMG) are major psychoactive constituents of kratom. While MG and 7‐HMG share behavioral and analgesic properties with morphine,
Scott E. Hemby, Scot McIntosh, Francisco Leon, Stephen J. Cutler, Christopher R. McCurdy   +4 more
openaire   +2 more sources

A Case of 7-Hydroxymitragynine Use Disorder Treated With Buprenorphine

Journal of Addiction Medicine
Background: Kratom is a plant widely consumed for the stimulant and opioid properties of its primary psychoactive component, mitragynine. A related compound, 7-hydroxymitragynine (7-HMG), also known colloquially as “7-OH,” “7-Hydroxy,” “7-OHMG,” or “7,” is present in kratom in smaller amounts but is much more ...
Reuben Hendler, Zoe Karavolis, Jungjin Kim, Gerardo Gonzalez   +3 more
openaire   +1 more source