Results 141 to 150 of about 824 (158)
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Planta Medica, 2014
Mitragyna speciosa (kratom) is a popular herb in Southeast Asia, which is traditionally used to treat withdrawal symptoms associated with opiate addiction. Mitragynine, 7-hydroxymitragynine, and mitraphylline are reported to be the central nervous system active alkaloids which bind to the opiate receptors.
Vamshi K, Manda +5 more
openaire +2 more sources
Mitragyna speciosa (kratom) is a popular herb in Southeast Asia, which is traditionally used to treat withdrawal symptoms associated with opiate addiction. Mitragynine, 7-hydroxymitragynine, and mitraphylline are reported to be the central nervous system active alkaloids which bind to the opiate receptors.
Vamshi K, Manda +5 more
openaire +2 more sources
Substance Use Disorder Following Consumption of a Novel Synthetic 7-Hydroxymitragynine Product
Journal of Addiction MedicineBackground: Products containing semi-synthetic 7-hydroxymitragynine (7-OH), a potent mu-opioid receptor (MOR) agonist, have proliferated in the United States. In kratom leaf, trace amounts of 7-OH are formed by spontaneous oxidization of kratom’s primary alkaloid, mitragynine.
Brandon Reif +5 more
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European Journal of Drug Metabolism and Pharmacokinetics
Kratom, a Southeast Asian tree, has been researched for its potential as a therapeutic for substance use disorders. The most abundant alkaloid in kratom, mitragynine, is being investigated individually for opioid use disorder. However, the active metabolite of mitragynine,7-hydroxymitragynine (7-HMG) has raised concerns because of its high binding ...
Yi-Hua Chiang +9 more
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Kratom, a Southeast Asian tree, has been researched for its potential as a therapeutic for substance use disorders. The most abundant alkaloid in kratom, mitragynine, is being investigated individually for opioid use disorder. However, the active metabolite of mitragynine,7-hydroxymitragynine (7-HMG) has raised concerns because of its high binding ...
Yi-Hua Chiang +9 more
openaire +2 more sources
The rise of novel, semi‐synthetic 7‐hydroxymitragynine products
AddictionEdward W Boyer +2 more
exaly +3 more sources
International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science
Kratom, a plant native to Southeast Asia, has gained attention as a potential alternative to opioids for pain relief and managing withdrawal symptoms. However, concerns about its safety persist due to reported adverse effects and drug interactions. Despite having at least 50 alkaloids, the pharmacological properties of kratom remain poorly understood ...
Nur Syahirunelisa Mohd Zubri +5 more
openaire +1 more source
Kratom, a plant native to Southeast Asia, has gained attention as a potential alternative to opioids for pain relief and managing withdrawal symptoms. However, concerns about its safety persist due to reported adverse effects and drug interactions. Despite having at least 50 alkaloids, the pharmacological properties of kratom remain poorly understood ...
Nur Syahirunelisa Mohd Zubri +5 more
openaire +1 more source
Journal of Analytical Toxicology
Abstract Kratom is a natural psychoactive product known primarily in Southeast Asia, including Thailand, Malaysia, etc. It is also known as krathom, kakuam, ithang, thom (Thailand), biak-biak, ketum (Malaysia) and mambog (Philippines) and is sometimes used as an opium substitute. It is stimulant at doses of 1–5 g, analgesic at doses of 5–
Jongsook Rhee +7 more
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Abstract Kratom is a natural psychoactive product known primarily in Southeast Asia, including Thailand, Malaysia, etc. It is also known as krathom, kakuam, ithang, thom (Thailand), biak-biak, ketum (Malaysia) and mambog (Philippines) and is sometimes used as an opium substitute. It is stimulant at doses of 1–5 g, analgesic at doses of 5–
Jongsook Rhee +7 more
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Determination of ADME properties of mitragynine, 7-hydroxymitragynine, and mitraphylline
Planta Medica, 2014VK Manda +5 more
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Journal of Separation Science
ABSTRACTA novel validated analytical approach implementing multisegment injection strategy into the capillary zone electrophoresis‐tandem mass spectrometry hyphenation for determination of two psychoactive alkaloids, mitragynine (MIT), and 7‐hydoxymitraginine (7‐OH‐MIT), in kratom raw samples was introduced.
Andrea Horniakova +2 more
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ABSTRACTA novel validated analytical approach implementing multisegment injection strategy into the capillary zone electrophoresis‐tandem mass spectrometry hyphenation for determination of two psychoactive alkaloids, mitragynine (MIT), and 7‐hydoxymitraginine (7‐OH‐MIT), in kratom raw samples was introduced.
Andrea Horniakova +2 more
openaire +2 more sources
Journal of Addiction Medicine
Background: 7-Hydroxymitragynine (7-OH) is a highly selective mu opioid receptor agonist with binding affinity greater than morphine. Although trace amounts of 7-OH are found in kratom, it is formed by metabolism in humans after kratom ingestion.
Kirsten E. Smith +7 more
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Background: 7-Hydroxymitragynine (7-OH) is a highly selective mu opioid receptor agonist with binding affinity greater than morphine. Although trace amounts of 7-OH are found in kratom, it is formed by metabolism in humans after kratom ingestion.
Kirsten E. Smith +7 more
openaire +2 more sources