Results 101 to 110 of about 1,092 (179)

Prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd), CareStart qualitative rapid diagnostic test performance, and genetic variants in two malaria-endemic areas in Sudan

PLoS Neglected Tropical Diseases, 2021
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common enzymopathy globally, and deficient individuals may experience severe hemolysis following treatment with 8-aminoquinolines.
Musab M. Ali Albsheer, Andrew A. Lover, Sara B. Eltom, Leena Omereltinai, Nouh Mohamed, Mohamed S. Muneer, Abdelrahim O. Mohamad, Muzamil Mahdi Abdel Hamid   +7 more
doaj  

Review: Improving the Therapeutic Index of 8-Aminoquinolines by the Use of Drug Combinations: Review of the Literature and Proposal for Future Investigations [PDF]

, 2011
Because 8-aminoquinolines affect critical survival stages of Plasmodium parasites, treatment and control of malaria could be markedly improved by more widespread use of these drugs; however, hemolytic toxicity, which is widely prevalent in G6PD-deficient
Baird, J. Kevin, Berman, Jonathan, Melendez, Victor, Myint, Hla Y., Ohrt, Colin, Pybus, Brandon, Walker, Larry   +6 more
core   +2 more sources

Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria

Malaria Journal, 2019
Background Glucose-6-phosphate dehydrogenase deficiency (G6PDd), haemoglobin C (HbC) and S (HbS) are inherited blood disorders (IBD) common in populations in malaria endemic areas.
Lynn Grignard, Catherine Mair, Jonathan Curry, Laleta Mahey, Guide J. H. Bastiaens, Alfred B. Tiono, Joseph Okebe, Sam A. Coulibaly, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, Kjerstin H. W. Lanke, Sodiomon B. Sirima, Umberto d’Alessandro, Taane G. Clark, Susana Campino, Teun Bousema, Chris Drakeley   +20 more
doaj   +1 more source

Chimiothérapie des theilérioses bovines par un anticoccidien, l'halofuginone : note préliminaire [PDF]

, 1980
L'anticoccidien halofuginone est un schizonticide puissant contre Theileria parva, agent de la fièvre de la Côte Est et de la Corridor disease des bovins en Afrique.
Franssen, F.F.J., Jongejan, Frans, Perié, N.M., Uilenberg, Gerrit   +3 more
core  

Prevalence and distribution of glucose-6-phosphate dehydrogenase (G6PD) variants in Thai and Burmese populations in malaria endemic areas of Thailand

Malaria Journal, 2011
Background G6PD deficiency is common in malaria endemic regions and is estimated to affect more than 400 million people worldwide. Treatment of malaria patients with the anti-malarial drug primaquine or other 8-aminoquinolines may be associated with ...
Phompradit Papichaya, Kuesap Jiraporn, Chaijaroenkul Wanna, Rueangweerayut Ronnatrai, Hongkaew Yaowaluck, Yamnuan Rujira, Na-Bangchang Kesara   +6 more
doaj   +1 more source

Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria

Malaria Journal, 2017
Background Control of malaria increasingly involves administration of 8-aminoquinolines, with accompanying risk of haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Katherine Plewes, Ingfar Soontarawirat, Aniruddha Ghose, Germana Bancone, Hugh W. F. Kingston, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Abul Faiz, Nicholas M. Anstey, Nicholas P. J. Day, Md. Amir Hossain, Mallika Imwong, Arjen M. Dondorp, Charles J. Woodrow   +14 more
doaj   +1 more source

Structures, targets and recent approaches in anti-leishmanial drug discovery and development. [PDF]

, 2011
Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002.
Seifert, Karin
core   +2 more sources

Pharmacology of 8-aminoquinolines.

Bulletin of the World Health Organization, 1982
The 8-aminoquinolines were the first group of compounds to be synthesized specifically for their antimalarial activity. A large-scale research programme in the United States of America in the 1940s produced three new antimalarial drugs-pentaquine, isopentaquine, and primaquine -of which primaquine was the most effective.
openaire   +1 more source

Recent Advances in the Treatment of Malaria

Pharmaceutics
Malaria is still one of the major global health challenges affecting millions annually, particularly in non-Mediterranean Africa and Southeast Asia. Over the past two decades, substantial progress has been made in reducing malaria-related morbidity and ...
Jawaher M. Alghamdi, Arwa A. Al-Qahtani, Fatimah S. Alhamlan, Ahmed A. Al-Qahtani   +3 more
doaj   +1 more source

8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models. [PDF]

, 1991
Three 8-aminoquinolines from the Walter Reed Army Institute for Research (WRAIR), WR6026, WR238605, and WR242511, strongly inhibited Pneumocystis carinii growth in vitro at 1 microgram/ml. This activity was similar to that of primaquine.
Bartlett, M. S., Queener, S. F., Tidwell, R. R., Milhous, W. K., Berman, J. D., Ellis, W. Y., Smith, J. W.   +6 more
core   +2 more sources