Results 41 to 50 of about 7,344 (147)

Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis

Journal of Lipid Research, 2002
Triparanol, an inhibitor of desmosterol Δ24 reductase, produces a high rate of limb malformations in rat fetuses exposed at gestational day 10 (gd 10) to a single oral dose (150–200 mg/kg) given to the pregnant dam.
Françoise Chevy, Françoise Illien, Claude Wolf, Charles Roux   +3 more
doaj   +1 more source

Potential of the Desert Locust Schistocerca gregaria (Orthoptera: Acrididae) as an Unconventional Source of Dietary and Therapeutic Sterols. [PDF]

PLoS ONE, 2015
Insects are increasingly being recognized not only as a source of food to feed the ever growing world population but also as potential sources of new products and therapeutic agents, among which are sterols.
Xavier Cheseto, Serge Philibert Kuate, David P Tchouassi, Mary Ndung'u, Peter E A Teal, Baldwyn Torto   +5 more
doaj   +1 more source

Use of determinations of 7-lathosterol (5 alpha-cholest-7-en-3 beta-ol) and other cholesterol precursors in serum in the study and treatment of disturbances of sterol metabolism, particularly cerebrotendinous xanthomatosis

Journal of Lipid Research, 1991
The sterol composition of sera from patients with cerebrotendinous xanthomatosis (CTX) was investigated by gas chromatographic analysis of saponified extracts, using a polar (CP Wax 52CB) and an apolar (CP Sil 5CB) capillary column.
BG Wolthers, HT Walrecht, JC van der Molen, GT Nagel, JJ Van Doormaal, PN Wijnandts   +5 more
doaj   +1 more source

Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation

Advanced Science, EarlyView.
The relative abundance of peroxidation‐resistant monounsaturated fatty acids (MUFAs) vs. peroxidation‐sensitive polyunsaturated fatty acids (PUFAs) incorporated into phospholipid (PL) is a key determinant of ferroptosis sensitivity, as the peroxidation of PL PUFA acyl chains (PUFA‐PL) disrupts membrane integrity, causing ferroptotic cell death ...
Shaojie Cui, Jin Ye
wiley   +1 more source

Conradi–Hunermann syndrome: A rare case of chondrodysplasia punctata

Indian Journal of Paediatric Dermatology, 2019
Conradi–Hunermann syndrome is a common form of chondrodysplasia punctata, inherited as X-linked dominant disorder of cholesterol metabolism due to mutation of emopamil-binding protein gene resulting in a spectrum of skeletal, cutaneous, and ocular ...
Rajkumar Motiram Meshram, Akhilesh A Dandale, Lakshmikant A Rohadkar, Ravi N Chirag   +3 more
doaj   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

eLife, 2015
Two parallel pathways produce cholesterol: the Bloch and Kandutsch-Russell pathways. Here we used stable isotope labeling and isotopomer analysis to trace sterol flux through the two pathways in mice.
Matthew A Mitsche, Jeffrey G McDonald, Helen H Hobbs, Jonathan C Cohen   +3 more
doaj   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Molecular Investigations on Angiogenesis and Oxidative Stress in Roe Deer (Capreolus capreolus) Bucks' Testes Throughout the Reproductive Cycle

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Animals with seasonal reproductive cycles, as the Roe deer (Capreolus capreolus), have developed mechanisms to synchronize reproduction with the environmental cycle in order to optimize reproductive success through melatonin. Angiogenesis and oxidative stress are key processes in spermatogenesis, contributing to testicular remodeling and ...
Ilaria Troisio, Domenico Ventrella, Bálint Lóránt Hausz, Mattia Cesauri, Niccolò Ian Vannetti, Maria Laura Bacci, Alberto Elmi, Augusta Zannoni   +7 more
wiley   +1 more source

Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites [PDF]

, 2020
There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D ...
William Griffiths, Yuqin Wang
core   +1 more source