Results 61 to 70 of about 1,352 (137)

(89)Zr, a radiometal nuclide with high potential for molecular imaging with PET: chemistry, applications and remaining challenges. [PDF]

, 2013
Molecular imaging-and especially Positron Emission Tomography (PET)-is of increasing importance for the diagnosis of various diseases and thus is experiencing increasing dissemination.
Fischer, Gabriel, Schirrmacher, Ralf, Seibold, Uwe, Wängler, Björn, Wängler, Carmen   +4 more
core   +3 more sources

Clear Cell Renal Cell Carcinoma: Rare and Atypical Metastatic Localizations—A Case Series

Case Reports in Urology, Volume 2026, Issue 1, 2026.
Introduction Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer, characterized by its high degree of vascularity and metastatic potential. Although common metastatic sites include the lungs, lymph nodes, bones, liver, adrenal glands, and brain, rare localizations, such as those observed in the pancreas, gallbladder ...
Roosvelt Tessa Djambong, Bril Laurel Follah Feudjio, Stéphane Rysselinck, Emmanuel Seront, Günter Niegisch, Christina Neppl, Alexander Müller, Kalyani Sen   +7 more
wiley   +1 more source

PET/CT Imaging of Zr-89-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys [PDF]

, 2020
PURPOSE: Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, the efficacy differs between patients.
Bennacef, Idriss, de Vries, Elisabeth G. E., Evelhoch, Jeffrey L., Gantert, Liza, Haley, Hyking, Holahan, Marie, Hostetler, Eric D., Hseih, SuChun, Judo, Michael, Klimas, Michael, Li, Wenping, Lub-de Hooge, Marjolijn N., Purcell, Mona, Rubins, Daniel, Seghezzi, Wolfgang, van der Veen, Elly L., Wang, Yuchuan, Zhang, Shuli   +17 more
core   +1 more source

Target engagement of an anti-MT1-MMP antibody for triple-negative breast cancer PET imaging and beta therapy [PDF]

13 p.-8 fig.-2 tab.Purpose: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that lacks effective diagnostic and therapeutic options.
Magro, Natalia, Oteo, Marta, Romero, Eduardo, Ibáñez-Moragues, Marta, Luján-Rodríguez, Víctor M., Martínez, Laura, Vela, Óscar, López-Melero, Maria Elena, Arroyo, Alicia G., Garaulet, Guillermo, Martínez-Torrecuadrada, Jorge Luis, Mulero, Francisca, Morcillo, Miguel Ángel   +12 more
core   +2 more sources

SUBDUE‐3: SUB‐urothelial DUrvalumab‐89zirconium injEction; a phase 0 biodistribution study protocol

BJU International, EarlyView.
Kevin G. Keane, Richard Gauci, Roslyn J. Francis, Andrew M. Scott, Cynthia Hawks, Andrisha‐Jade Inderjeeth, Ian D. Davis, Jayne Lim, Andrew Redfern, Dickon Hayne   +9 more
wiley   +1 more source

Non‐FDG‐Avid Metastasis Detected by Molecular Imaging in Unknown Primary of the Head and Neck

The Laryngoscope, Volume 135, Issue 9, Page 3229-3231, September 2025.
In a patient with squamous cell carcinoma of unknown primary, the use of molecular imaging identified an additional site of metastasis not seen on traditional PET/CT. This aided in proper diagnosis and alteration of the patient's treatment plan. ABSTRACT Squamous cell carcinoma of unknown primary continues to be a diagnostic challenge.
Nicole Meeks, Ashtyn McAdoo, Jaclyn Lee, Marisa Hom, Gary Smith, Melanie Hicks, Kyle Mannion, Eben Rosenthal, Michael C. Topf   +8 more
wiley   +1 more source

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, Volume 12, Issue 29, August 7, 2025.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source

PET imaging of colon cancer CD73 expression using cysteine site-specific 89Zr-labeled anti-CD73 antibody

Scientific Reports
CD73 is a cell-surface ectoenzyme that hydrolyzes the conversion of extracellular adenosine monophosphate to adenosine, which in turn can promote resistance to immune checkpoint blockade therapy.
Kyung-Ho Jung, Mina Kim, Hye Jin Jung, Hyun Jung Koo, Jung-Lim Kim, Hyunjong Lee, Kyung-Han Lee   +6 more
doaj   +1 more source

CD70: An emerging target for integrated cancer diagnosis and therapy

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
CD70 is aberrantly overexpressed in diverse tumours with limited normal tissue expression, making it a compelling diagnostic and therapeutic target. Immuno‐PET/CT facilitates tumour detection, staging, and treatment monitoring. Multiple CD70‐targeted therapies are under early evaluation. Rational combination strategies are emerging to enhance antitumor
Jiatao Hu, Jinxin Li, Bo Yang, Siyi Wang, Yi Bao, Yiren Yang, Kun Qiao, Fei Guo, Xinxin Gan, Linhui Wang   +9 more
wiley   +1 more source

Fluorescent Deferoxamine Complexes of Cu(II) and Zr(IV): Insights in the Development of Dual Imaging Probes

Chemistry – A European Journal, Volume 31, Issue 35, June 23, 2025.
The insertion of a fluorescent coumarin unit by using a lysine‐based linker on deferoxamine leads to a chelating agent (DFOKC), whose Cu(II) and Zr(IV) complexes can be used for both optical imaging and positron emission tomography. DFOKC shows increased binding ability for Cu(II) and Zr(II) and improved tumor cell internalization via pinocytosis ...
Yschtar Tecla Simonini Steiner, Virginia Zizi, Monica Mangoni, Patrizia Nardini, Daniele Bani, Andrea Bencini, Antonio Bianchi, Matteo Savastano, Giammarco Maria Romano   +8 more
wiley   +1 more source