Results 71 to 80 of about 1,352 (137)

Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications

EJNMMI Radiopharmacy and Chemistry
Background Positron emission tomography (PET) is a highly sensitive method that provides fine resolution images, useful in the field of clinical diagnostics.
Valentina Albanese, Chiara Roccatello, Salvatore Pacifico, Remo Guerrini, Delia Preti, Silvia Gentili, Matteo Tegoni, Maurizio Remelli, Denise Bellotti, Jonathan Amico, Giancarlo Gorgoni, Emiliano Cazzola   +11 more
doaj   +1 more source

Positron emission tomography in breast cancer: 18F- FDG and other radiopharmaceuticals

European Journal of Hybrid Imaging, 2018
Background Breast cancer heterogeneity reflects the complex biology of this disease. Breast cancer subtypes, as identified either by immunohistochemistry (IHC) or by gene expression analysis, present different molecular characteristics and prognosis.
Ioannis Iakovou, Evanthia Giannoula, Areti Gkantaifi, Sofia Levva, Savvas Frangos   +4 more
doaj   +1 more source

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen, Keying Zhu, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Min Yang   +8 more
wiley   +1 more source

PD-L1 detection using 89Zr-atezolizumab immuno-PET in renal cell carcinoma tumorgrafts from a patient with favorable nivolumab response

Journal for ImmunoTherapy of Cancer, 2019
Background Programmed death-ligand 1 (PD-L1) expression in metastatic renal cell carcinoma (RCC) correlates with a worse prognosis, but whether it also predicts responsiveness to anti-PD-1/PD-L1 therapy remains unclear.
Joseph Vento, Aditi Mulgaonkar, Layton Woolford, Kien Nham, Alana Christie, Aditya Bagrodia, Alberto Diaz de Leon, Raquibul Hannan, Isaac Bowman, Renee M. McKay, Payal Kapur, Guiyang Hao, Xiankai Sun, James Brugarolas   +13 more
doaj   +1 more source

Facts and hopes for PET imaging-derived immunotherapy biomarkers [PDF]

Current immunotherapies have brought major progress in cancer treatments, but not all patients benefit. Therefore, insight into reasons for treatment failure and optimal biomarkers for patient selection are warranted.
Brouwers, Adrienne H, de Groot, Derk Jan A, de Vries, Elisabeth G E, Lub-de Hooge, Marjolijn N, van Meerten, Tom   +4 more
core   +1 more source

Leveraging In Silico and Artificial Intelligence Models to Advance Drug Disposition and Response Predictions Across the Lifespan

Clinical and Translational Science, Volume 18, Issue 6, June 2025.
ABSTRACT Incorporating inter‐individual differences in drug disposition and responses is essential for ensuring the safe and effective use of drugs in real‐world patients. Despite ongoing efforts, lower participation of children, older individuals, pregnant and breastfeeding women, postmenopausal women, and people with disease states and disabilities ...
Kyunghee Yang, Daniel Gonzalez, Jeffrey L. Woodhead, Pallavi Bhargava, Murali Ramanathan   +4 more
wiley   +1 more source

Imaging antigen processing and presentation in cancer [PDF]

Introduction: Antigen processing and presentation are vital processes of the adaptive immunity. These processes involve a series of intracellular and extracellular events, including the enzymology within cells during antigen processing, the loading and ...
Elliott, Tim, Lau, Doreen
core   +5 more sources

Tumor‐Associated Carbohydrate Antigen 19–9 (CA 19–9), a Promising Target for Antibody‐Based Detection, Diagnosis, and Immunotherapy of Cancer

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
Carbohydrate antigen 19–9 (CA 19–9), also known as sialyl Lewis A, is a tetrasaccharide overexpressed on a wide range of cancerous cells, most prominently pancreatic ductal adenocarcinoma. The review discusses the synthesis of CA 19–9, elicitation of antibodies through vaccination, development of anti‐CA 19–9 monoclonal antibodies, and their ...
Athar Nakisa, Lorenzo F. Sempere, Xi Chen, Linda T. Qu, Daniel Woldring, Howard C. Crawford, Xuefei Huang   +6 more
wiley   +1 more source

Octadentate zirconium(IV)-loaded macrocycles with varied stoichiometry assembled from hydroxamic acid monomers using metal-templated synthesis [PDF]

, 2017
Published: February 28, 2017The reaction between Zr(IV) and the forward endo-hydroxamic acid monomer 4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoic acid (for-PBH) in a 1:4 stoichiometry in the presence of diphenylphosphoryl azide and triethylamine gave ...
Codd, R., Katsifis, A., Lifa, T., Tieu, W.   +3 more
core   +2 more sources

⁸⁹Zr-Immuno-PET with Immune Checkpoint Inhibitors: Measuring Target Engagement in Healthy Organs. [PDF]

Cancers (Basel), 2023
Miedema IHC, Wijngaarden JE, Pouw JEE, Zwezerijnen GJC, Sebus HJ, Smit E, de Langen AJ, Bahce I, Thiele A, Vugts DJ, Boellaard R, Huisman MC, Menke-van der Houven van Oordt CW.   +12 more
europepmc   +1 more source