Results 81 to 90 of about 1,508,590 (281)

A hierarchy in clusters of cephalopod mRNA editing sites

Scientific Reports, 2022
RNA editing in the form of substituting adenine with inosine (A-to-I editing) is the most frequent type of RNA editing in many metazoan species. In most species, A-to-I editing sites tend to form clusters and editing at clustered sites depends on editing
Mikhail A. Moldovan, Zoe S. Chervontseva, Daria S. Nogina, Mikhail S. Gelfand   +3 more
doaj   +1 more source

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

Nature Communications, 2018
Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing.
Guermarie Velázquez-Torres, E. Shoshan, C. Ivan, Li Huang, E. Fuentes-Mattei, Harrison Paret, S. J. Kim, Cristian Rodríguez-Aguayo, Victoria K. Xie, Denise Brooks, Steven J. M. Jones, A. G. Robertson, G. Calin, G. López-Berenstein, A. Sood, M. Bar‐eli   +15 more
semanticscholar   +1 more source

Is abundant A-to-I RNA editing primate-specific? [PDF]

Trends in Genetics, 2005
preprint version; final version available at http://dx.doi.org/10.1016/j.tig.2004.12 ...
Eisenberg, Eli, Nemzer, Sergey, Kinar, Yaron, Sorek, Rotem, Rechavi, Gideon, Levanon, Erez Y.   +5 more
openaire   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Illuminating spatial A-to-I RNA editing signatures within the Drosophila brain

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance A fundamental question in contemporary neuroscience is how the remarkable cellular diversity required for the intricate function of the nervous system is achieved.
Anne L. Sapiro, A. Shmueli, G. L. Henry, Qin Li, Tali Shalit, O. Yaron, Y. Paas, Jin Billy Li, Galit Shohat-Ophir   +8 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The evolution and adaptation of A-to-I RNA editing

PLOS Genetics, 2017
Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein. RNA editing can generate a multitude of transcript isoforms and can potentially be used to optimize protein function in response to varying conditions.
Arielle L. Yablonovitch, Patricia Deng, Dionna Jacobson, Jin Billy Li   +3 more
openaire   +4 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source