Results 91 to 100 of about 574,299 (199)
The role of A-to-I RNA editing in cancer development [PDF]
Current Opinion in Genetics & Development, 2018 Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans, which is catalyzed in ADAR enzymes. Recent genomic studies have revealed thousands of altered RNA editing events in various cancer tissues, leading to diverse functional consequences.
Xiaoyan, Xu, Yumeng, Wang, Han, Liang
openaire +2 more sources
A Role for A-to-I RNA Editing in Temperature Adaptation [PDF]
Physiology, 2012 A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to smaller, less stabilizing amino acids. Studies on how editing affects protein function support this idea.
Sandra C, Garrett, Joshua J C, Rosenthal
openaire +2 more sources
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. [PDF]
, 2015 Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Alon, S +10 more
core +2 more sources
A-to-I RNA Editing Affects lncRNAs Expression after Heat Shock [PDF]
Genes, 2018 Adenosine to inosine (A-to-I) RNA editing is a highly conserved regulatory process carried out by adenosine-deaminases (ADARs) on double-stranded RNA (dsRNAs). Although a considerable fraction of the transcriptome is edited, the function of most editing sites is unknown.
Roni Haas +5 more
openaire +2 more sources
FairBase: a comprehensive database of fungal A-to-I RNA editing [PDF]
Database, 2019 Frequent A-to-I RNA editing has recently been identified in fungi despite the absence of recognizable homologues of metazoan ADARs ("Adenosine Deaminases Acting on RNA"). In particular, there is emerging evidence showing that A-to-I editing is involved in sexual reproduction of filamentous fungi. Here, we report on the creation of FairBase - a fungal A-
Liu, Jinding +7 more
openaire +2 more sources
BMC Research Notes, 2012 Background A-to-I RNA editing is found in all phyla of animals and contributes to transcript diversity that may have profound impacts on behavior and physiology.
Rinkevich Frank D +2 more
doaj +1 more source
Genome Biology, 2023 Single-molecule detection and phasing of A-to-I RNA editing events remain an unresolved problem. Long-read and PCR-free nanopore native RNA sequencing offers a great opportunity for direct RNA editing detection.
Longxian Chen +9 more
doaj +1 more source
SPsimSeq : semi-parametric simulation of bulk and single-cell RNA-sequencing data [PDF]
, 2020 SPsimSeq is a semi-parametric simulation method to generate bulk and single-cell RNA-sequencing data. It is designed to simulate gene expression data with maximal retention of the characteristics of real data.
Assefa, Alemu Takele +2 more
core +1 more source
RADAR: a rigorously annotated database of A-to-I RNA editing [PDF]
Nucleic Acids Research, 2013 We present RADAR--a rigorously annotated database of A-to-I RNA editing (available at http://RNAedit.com). The identification of A-to-I RNA editing sites has been dramatically accelerated in the past few years by high-throughput RNA sequencing studies.
Ramaswami, Gokul, Li, Jin Billy
openaire +2 more sources
A Newly Discovered Bordetella Species Carries a Transcriptionally Active CRISPR-Cas with a Small Cas9 Endonuclease [PDF]
, 2015 Background Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (cas) are widely distributed among bacteria.
Dudley, Edward G. +7 more
core +2 more sources