Results 171 to 180 of about 574,299 (199)
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Genome-Wide Analysis of A-to-I RNA Editing.
Methods in molecular biology, 2016Adenosine (A)-to-inosine (I) RNA editing is a fundamental posttranscriptional modification that ensures the deamination of A-to-I in double-stranded (ds) RNA molecules. Intriguingly, the A-to-I RNA editing system is particularly active in the nervous system of higher eukaryotes, altering a plethora of noncoding and coding sequences.
Yiannis A. Savva, G. Laurent, R. Reenan
semanticscholar +3 more sources
Aptazyme-directed A-to-I RNA editing.
Methods in EnzymologyAs a promising therapeutic approach, the RNA editing process can correct pathogenic mutations and is reversible and tunable, without permanently altering the genome. RNA editing mediated by human ADAR proteins offers unique advantages, including high specificity and low immunogenicity.
Xilei Ai, Zhuo Tang
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Short-Chain Guide RNA for Site-Directed A-to-I RNA Editing
Nucleic Acid Therapeutics, 2021Site-directed RNA editing is a promising genetic modification technology for therapeutic and pharmaceutical applications. We previously constructed adenosine deaminases acting on RNA (ADAR)-guiding RNAs (AD-gRNAs) that direct A-to-I RNA editing activity of native human ADAR2 into a programmable target site.
Kanako, Nose +4 more
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A-to-I RNA Editing is Induced Upon Hypoxia
Shock, 2011Regulating gene expression is part of a cell's response to hypoxia. A-to-I RNA editing is an epigenetic phenomenon that can contribute to RNA and protein levels and to isoform diversity. In this study, we identified alterations in the levels of RNA editing following hypoxic stress in three genes: MED13, STAT3, and F11R.
Yael, Nevo-Caspi +3 more
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Perturbing A-to-I RNA editing using genetics and homologous recombination.
Methods in molecular biology, 2011Evidence for the chemical conversion of adenosine-to-inosine (A-to-I) in messenger RNA (mRNA) has been detected in numerous metazoans, especially those "most successful" phyla: Arthropoda, Mollusca, and Chordata. The requisite enzymes for A-to-I editing, ADARs (adenosine deaminases acting on RNA) are highly conserved and are present in every higher ...
Cynthia Staber +3 more
semanticscholar +3 more sources
Detection of A-to-I Hyper-edited RNA Sequences
2020Following A-to-I editing of double-stranded RNA (dsRNA) molecules, sequencing reactions interpret the edited inosine (I) as guanosine (G). For this reason, current methods to detect A-to-I editing sites work to align RNA sequences to their reference DNA sequence in order to reveal A-to-G mismatches.
Roni, Cohen-Fultheim, Erez Y, Levanon
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A-to-I editing of protein coding and noncoding RNAs
Critical Reviews in Biochemistry and Molecular Biology, 2012Adenosine deaminase acting on RNA (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) substrates. Inosine pairs preferentially with cytidine, as opposed to uridine; therefore, ADAR editing alters the sequence and base pairing properties of both protein-coding and non-coding RNA.
Arka, Mallela, Kazuko, Nishikura
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A-to-I RNA Editing in Human Cells
2021A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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A-to-I RNA editing as a tuner of noncoding RNAs in cancer
Cancer Letters, 2020Recent advancement in RNA technology and computation biology shows the abundance and impact of RNA editing at the genome-wide level. Of RNA editing events, Adenosine-to-inosine (A-to-I) RNA editing is one of the most frequent types of RNA editing catalyzed by ADAR proteins.
Yuanfan Liao, Seung Ho Jung, Taewan Kim
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A-to-I RNA editing in autism spectrum disorder
, 2014A. Eran, I. Kohane, L. Kunkel
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