Results 191 to 200 of about 134,460,322 (302)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Development of the Site-directed RNA Editing Utilizing Intracellular A-to-I RNA Editing

Development of the Site-directed RNA Editing Utilizing Intracellular A-to-I RNA Editing
2020
openaire   +1 more source

A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR. [PDF]

Nat Commun
Yi Y, Li Y, Wang R, Yu X, Liu Q, Yum C, Zhang Y, Qiao Y, Szczepanski A, Wu S, Li Q, Fazli L, Shen J, Wang X, Li X, Mu P, Schaeffer EM, Hundley HA, Niu H, Chinnaiyan AM, Wang L, Shi J, Jin J, Dong X, Zhao W, Chen K, Cao Q.   +26 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

ADAR1 and ADAR2 Expression in the Thoracic Aortic Wall Correlates with Aneurysm Severity and Dissection Risk: Insights into A-to-I RNA Editing Dysregulation in Marfan Syndrome-Derived vSMCs. [PDF]

Int J Mol Sci
Pisano C, Colopi A, Silvestris DA, Terriaca S, Guida E, Porreca A, Sbrigata A, Doronzio PN, Orlandi A, Dolci S, La Rosa P, Cesarini V.   +11 more
europepmc   +1 more source

Deep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus. [PDF]

BMC Biol, 2023
Nguyen TA, Heng JWJ, Ng YT, Sun R, Fisher S, Oguz G, Kaewsapsak P, Xue S, Reversade B, Ramasamy A, Eisenberg E, Tan MH.   +11 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

A transcriptome-wide systematic search does not detect A-to-I RNA editing in <i>cis</i>-antisense RNA duplexes. [PDF]

Genome Res
Rosenwasser Z, Cohen-Fultheim R, Shliefer O, Levanon EY, Eisenberg E.   +4 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

EndoV does not measurably affect TadA-dependent A-to-I RNA editing in <i>Escherichia coli</i> under exponential-growth conditions in rich medium. [PDF]

Microbiol Spectr
Fargeon O, Bar-Yaacov D.
europepmc   +1 more source