Results 211 to 220 of about 459,217 (330)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identification of ADAR1i-124: The first effective A-to-I RNA editing inhibitor with promising cancer therapeutic potential. [PDF]

iScience
Minakuchi M, Zhang H, Cassel J, Shiromoto Y, Villanueva J, Skordalakes E, Salvino JM, Li Q, Nishikura K.   +8 more
europepmc   +1 more source

ATTIC is an integrated approach for predicting A-to-I RNA editing sites in three species. [PDF]

Brief Bioinform, 2023
Chen R, Li F, Guo X, Bi Y, Li C, Pan S, Coin LJM, Song J.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Nomogram Based on A-To-I RNA Editing for Predicting Overall Survival in Patients With Breast Cancer. [PDF]

J Cell Mol Med
Zhang Y, Zhou J, Li H, Chai D, Lian B, Liu Y, Guo L, Li J.   +7 more
europepmc   +1 more source

A-to-I RNA Editing in Klebsiella pneumoniae Regulates Quorum Sensing and Affects Cell Growth and Virulence. [PDF]

Adv Sci (Weinh), 2023
Yang XZ, Sun TS, Jia PY, Li SJ, Li XG, Shi Y, Li X, Gao H, Yin H, Jia XM, Yang Q.   +10 more
europepmc   +1 more source

VIRES: visualization and identification of A-to-I RNA editing sites in genomic sequences

, 2012
Motivations. RNA Editing is a type of post-transcriptional modification that takes place in the eukaryotes and represents one of the last frontiers of molecular biology.
Macca V, Ferro A., Pulvirenti A, GIUGNO, ROSALBA, Distefano, Rosario, Nigita G   +5 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Signal peptides restrict genome evolution and A-to-I RNA editing. [PDF]

NAR Genom Bioinform
Duan Y, Chen S, Cai W, Song W, Li H.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source