Results 231 to 240 of about 459,217 (330)

Autorecoding A-to-I RNA editing sites in the Adar gene underwent compensatory gains and losses in major insect clades. [PDF]

RNA, 2023
Duan Y, Ma L, Song F, Tian L, Cai W, Li H.   +5 more
europepmc   +1 more source

Unraveling pleiotropic functions of A-To-I RNA editing in Drosophila

Fly, 2010
J. Jepson, R. Reenan
semanticscholar   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus. [PDF]

RNA Biol
Lattuca R, Bascetin R, Detours V, Lafontaine DLJ.   +3 more
europepmc   +1 more source

A-to-I RNA Editing: A Contribution to Diversity of the Transcriptome and an Organism’s Development

Biochemistry (Moscow), 2010
A. A. Zamyatnin, K. G. Lyamzaev, R. Zinovkin   +2 more
semanticscholar   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A-to-I RNA editing of <i>CYP18A1</i> mediates transgenerational wing dimorphism in aphids. [PDF]

Elife
Zhu B, Wei R, Hua W, Li L, Zhang W, Liang P.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

CircAI: a comprehensive database of CircRNA associated with A-to-I RNA editing. [PDF]

Database (Oxford)
Wang Y, Zou L, Zhao J, Wu J, Zhang M, Liu J, Wang Q, Guo X, Song X, Wang Y.   +9 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source