Results 171 to 180 of about 134,460,322 (302)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Evaluating the adaptive hypothesis of A-to-I RNA editing in filamentous ascomycete fungi. [PDF]

Mol Biol Evol
Li J, Jiang D, Zhang J.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Inefficient A-to-I RNA editing and ALS

Rinsho Shinkeigaku, 2010
openaire   +3 more sources

VIRES: visualization and identification of A-to-I RNA editing sites in genomic sequences

, 2012
Motivations. RNA Editing is a type of post-transcriptional modification that takes place in the eukaryotes and represents one of the last frontiers of molecular biology.
Macca V, Ferro A., Pulvirenti A, GIUGNO, ROSALBA, Distefano, Rosario, Nigita G   +5 more
core   +1 more source

A cytoplasmic index for quantifying immune-related A-to-I RNA editing. [PDF]

Genome Biol
Cohen-Fultheim R, Twersky I, Krupkin H, Roth SH, Levanon EY, Eisenberg E.   +5 more
europepmc   +1 more source

Identification and Interpretation of A-to-I RNA Editing Events in Insect Transcriptomes. [PDF]

Int J Mol Sci, 2023
Xu Y, Liu J, Zhao T, Song F, Tian L, Cai W, Li H, Duan Y.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A-to-I RNA editing profiles and distinct immune responses in myelin oligodendrocyte glycoprotein antibody-positive optic neuritis. [PDF]

Front Immunol
Cui X, Ding J, Fu X, Cheng F, Zhang Y, Zou W.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source