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A-to-I RNA editing — immune protector and transcriptome diversifier
Nature Reviews Genetics, 2018Modifications of RNA affect its function and stability. RNA editing is unique among these modifications because it not only alters the cellular fate of RNA molecules but also alters their sequence relative to the genome. The most common type of RNA editing is A-to-I editing by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes.
Eli Eisenberg, Erez Y. Levanon
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A-to-I RNA editing: The “ADAR” side of human cancer
Seminars in Cell & Developmental Biology, 2012Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human ...
Galeano, Federica +3 more
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A-to-I and C-to-U editing within transfer RNAs
Biochemistry (Moscow), 2011A significant number of post-transcriptional changes occur during the generation of mature transfer RNAs (tRNAs). These changes within precursor-tRNA molecules include the processing of 5' and 3' termini, the introduction of modifications, and also RNA editing. In this review, we will detail the reported cases of A-to-I and C-to-U tRNA editing.
Su, A., Randau, L.
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Genome wide quantification of A-to-I RNA editing activity
, 2019Adenosine to inosine (A-to-I) RNA editing by the ADAR enzymes is a common RNA modification, preventing false activation of the innate immune system by endogenous dsRNAs. Methods for quantification of ADAR activity are sought after, due to an increasing
S. H. Roth, E. Levanon, E. Eisenberg
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ALU A-to-I RNA Editing: Millions of Sites and Many Open Questions.
Methods in molecular biology, 2021Amos A Schaffer, E. Levanon
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Pathological RNA-protein inclusions and dysregulated A-to-I RNA editing in synucleinopathies
NeuronAggregation of RNA binding proteins and dysregulation of RNA metabolism drives pathogenesis of multiple neurodegenerative diseases. In this issue of Neuron, Belur et al.1 identified pathological NONO/SFPQ inclusions and aberrant A-to-I-edited RNAs accumulated in nucleus, leading to dysregulation of gene expression and neurodegeneration in ...
Rong, Wu, Shuying, Sun
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A-to-I editing prevents self-RNA sensing
Nature Reviews Molecular Cell Biology, 2022openaire +2 more sources
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Science AdvancesRNA editing is a posttranscriptional mechanism that targets changes in RNA transcripts to modulate innate immune responses. We report the role of astrocyte-specific, ADAR1-mediated RNA editing in neuroinflammation in Parkinson’s disease (PD).
Karishma D’Sa +30 more
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Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila
Nature Structural &Molecular Biology, 2013G. Laurent +9 more
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Obstacles in quantifying A-to-I RNA editing by Sanger sequencing
Adenosine-to-Inosine (A-to-I) RNA editing is the most prevalent type of RNA editing, in which adenosine within a completely or largely double-stranded RNA (dsRNA) is converted to inosine by deamination. RNA editing was shown to be involved in many neurological diseases and cancer; therefore, detection of A-to-I RNA editing and quantitation of editing ...Alla, Fishman, Ayelet T, Lamm
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