Results 251 to 260 of about 584,058 (291)

Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing. [PDF]

Cell Rep
Rivera M, Zhang H, Pham J, Isquith J, Zhou QJ, Balaian L, Sasik R, Enlund S, Mark A, Ma W, Holm F, Fisch KM, Kuo DJ, Jamieson C, Jiang Q.   +14 more
europepmc   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway. [PDF]

Exp Hematol Oncol
Wang H, Wei X, Liu L, Zhang J, Li H.
europepmc   +1 more source

Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception. [PDF]

Int J Mol Sci
Chen HW, Ma CP, Chin E, Chen YT, Wang TC, Kuo YP, Su CH, Huang PJ, Tan BC.   +8 more
europepmc   +1 more source

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A-to-I RNA editing — immune protector and transcriptome diversifier

Nature Reviews Genetics, 2018
Modifications of RNA affect its function and stability. RNA editing is unique among these modifications because it not only alters the cellular fate of RNA molecules but also alters their sequence relative to the genome. The most common type of RNA editing is A-to-I editing by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes.
Eli Eisenberg, Erez Y. Levanon
openaire   +5 more sources

A-to-I editing prevents self-RNA sensing

Nature Reviews Molecular Cell Biology, 2022
Leilei Chen
openaire   +4 more sources

Short-Chain Guide RNA for Site-Directed A-to-I RNA Editing

Nucleic Acid Therapeutics, 2021
Site-directed RNA editing is a promising genetic modification technology for therapeutic and pharmaceutical applications. We previously constructed adenosine deaminases acting on RNA (ADAR)-guiding RNAs (AD-gRNAs) that direct A-to-I RNA editing activity of native human ADAR2 into a programmable target site.
Kanako, Nose, Kota, Hidaka, Takashi, Yano, Yohei, Tomita, Masatora, Fukuda   +4 more
openaire   +2 more sources

A-to-I RNA Editing is Induced Upon Hypoxia

Shock, 2011
Regulating gene expression is part of a cell's response to hypoxia. A-to-I RNA editing is an epigenetic phenomenon that can contribute to RNA and protein levels and to isoform diversity. In this study, we identified alterations in the levels of RNA editing following hypoxic stress in three genes: MED13, STAT3, and F11R.
Yael, Nevo-Caspi, Ninette, Amariglio, Gideon, Rechavi, Gideon, Paret   +3 more
openaire   +2 more sources