Results 81 to 90 of about 574,299 (199)

Epitranscriptomic investigation of myopia-associated RNA editing in the retina

Frontiers in Neuroscience, 2023
Myopia is one of the most common causes of vision loss globally and is significantly affected by epigenetics. Adenosine-to-inosine (A-to-I RNA) editing is an epigenetic process involved in neurological disorders, yet its role in myopia remains ...
Xu-Bin Pan, Xu-Bin Pan, Xu-Bin Pan, Xu-Bin Pan, Yu-Shan He, Yu-Shan He, Yu-Shan He, Zijing Lu, Zijing Lu, Zijing Lu, Zijing Lu, Hao-Ran Pan, Hao-Ran Pan, Hao-Ran Pan, Hao-Ran Pan, Zhi-Yuan Wei, Zhi-Yuan Wei, Zhi-Yuan Wei, Yun-Yun Jin, Yun-Yun Jin, Yun-Yun Jin, Jihong Wang, Jian-Huan Chen, Jian-Huan Chen, Jian-Huan Chen   +24 more
doaj   +1 more source

Identification of novel components of Trypanosoma brucei editosomes [PDF]

, 2003
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Carmean, Nicole, Ernst, Nancy L, Panigrahi, Aswini K, Salavati, Reza, Schnaufer, Achim, Stuart, Kenneth, Wang, Bingbing   +6 more
core   +2 more sources

Is abundant A-to-I RNA editing primate-specific? [PDF]

Trends in Genetics, 2005
preprint version; final version available at http://dx.doi.org/10.1016/j.tig.2004.12 ...
Eisenberg, Eli, Nemzer, Sergey, Kinar, Yaron, Sorek, Rotem, Rechavi, Gideon, Levanon, Erez Y.   +5 more
openaire   +3 more sources

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]

, 2016
Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien, Callewaert, Bert, Coucke, Paul, De Paepe, Anne, De Rocker, Nina, Menten, Björn, Steyaert, Wouter, Willaert, Andy   +7 more
core   +2 more sources

A-to-I RNA editing independent of ADARs in filamentous fungi [PDF]

RNA Biology, 2016
ADAR mediated A-to-I RNA editing is thought to be unique to animals and occurs mainly in the non-coding regions. Recently filamentous fungi such as Fusarium graminearum were found to lack orthologs of animal ADARs but have stage-specific A-to-I editing during sexual reproduction.
Chenfang, Wang, Jin-Rong, Xu, Huiquan, Liu   +2 more
openaire   +2 more sources

Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans

RNA: A publication of the RNA Society, 2016
Adenosine-to-inosine RNA editing by ADARs affects thousands of adenosines in an organism's transcriptome. However, adenosines are not edited at equal levels nor do these editing levels correlate well with ADAR expression levels.
Michael C. Washburn, H. Hundley
semanticscholar   +1 more source

Interplay between A-to-I Editing and Splicing of RNA: A Potential Point of Application for Cancer Therapy

International Journal of Molecular Sciences, 2022
Adenosine-to-inosine RNA editing is a system of post-transcriptional modification widely distributed in metazoans which is catalyzed by ADAR enzymes and occurs mostly in double-stranded RNA (dsRNA) before splicing.
A. O. Goncharov, V. O. Shender, Ksenia G. Kuznetsova, Anna A. Kliuchnikova, S. Moshkovskii   +4 more
semanticscholar   +1 more source

Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]

, 2012
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Achim Schnaufer, Alatortsev, Ammerman, Aphasizheva, Aphasizheva, Bailey, Borst, Carnes, Carnes, Carnes, Cruz-Reyes, Cruz-Reyes, Deschamps, Ernst, Ernst, Etheridge, Fisk, Guo, Guo, Guo, Hashimi, Igo, Igo, Inoue, Jason Carnes, Jensen, Kao, Kenneth Stuart, Koslowsky, Koslowsky, Lukes, Mattiacio, Mattiacio, Melissa Lerch, Militello, Nathalie Acestor, Niemann, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Piller, Rigaut, Ryan, Sabatini, Schnaufer, Schnaufer, Seiwert, Simpson, Stuart, Trotter, Weng, Wirtz, Worthey, Xuemin Guo, Zhang   +58 more
core   +1 more source

ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts

Frontiers in Cell and Developmental Biology, 2023
Despite hundreds of RNA modifications described to date, only RNA editing results in a change in the nucleotide sequence of RNA molecules compared to the genome.
Riccardo Pecori, Riccardo Pecori, Isabel Chillón, Claudio Lo Giudice, Annette Arnold, Sandra Wüst, Marco Binder, Marco Marcia, Ernesto Picardi, Fotini Nina Papavasiliou   +9 more
doaj   +1 more source

A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer [PDF]

Cancer Cell, 2018
Adenosine (A) to inosine (I) RNA editing introduces many nucleotide changes in cancer transcriptomes. However, due to the complexity of post-transcriptional regulation, the contribution of RNA editing to proteomic diversity in human cancers remains unclear. Here, we performed an integrated analysis of TCGA genomic data and CPTAC proteomic data. Despite
Xinxin, Peng, Xiaoyan, Xu, Yumeng, Wang, David H, Hawke, Shuangxing, Yu, Leng, Han, Zhicheng, Zhou, Kamalika, Mojumdar, Kang Jin, Jeong, Marilyne, Labrie, Yiu Huen, Tsang, Minying, Zhang, Yiling, Lu, Patrick, Hwu, Kenneth L, Scott, Han, Liang, Gordon B, Mills   +16 more
openaire   +2 more sources