Results 21 to 30 of about 83,344 (312)

Central Activation of the A1 Adenosine Receptor (A1AR) Induces a Hypothermic, Torpor-Like State in the Rat

Journal of Neuroscience, 2013
Since central activation of A1 adenosine receptors (A1ARs) plays an important role in the induction of the hypothermic and hypometabolic torpid state in hibernating mammals, we investigated the potential for the A1AR agonist N6-cyclohexyladenosine to ...
D. Tupone, C. Madden, S. Morrison
semanticscholar   +1 more source

Impaired Inhibitory Function of Presynaptic A1-Adenosine Receptors in SHR Mesenteric Arteries

Journal of Pharmacological Sciences, 2013
In hypertension, vascular reactivity alterations have been attributed to numerous factors, including higher sympathetic innervation/adenosine. This study examined the modulation of adenosine receptors on vascular sympathetic nerves and their putative ...
Carolina Rocha-Pereira, Silvia Magdalena Arribas, Paula Fresco, Maria Carmen González, Jorge Gonçalves, Carmen Diniz   +5 more
doaj   +1 more source

Involvement of adenosine signaling pathway in migraine pathophysiology: a systematic review of preclinical studies

The Journal of Headache and Pain, 2022
Background Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist ...
Janu Thuraiaiyah, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Messoud Ashina   +3 more
doaj   +1 more source

The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

Molecules, 2011
The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or ...
Michal Hofer, Milan Pospisil, Zuzana Hoferova, Lenka Weiterova   +3 more
doaj   +1 more source

Identification of the Adenine Binding Site of the Human A1 Adenosine Receptor*

Journal of Biological Chemistry, 1999
To provide new insights into ligand-A1 adenosine receptor (A1AR) interactions, site-directed mutagenesis was used to test the role of several residues in the first four transmembrane domains of the human A1AR.
S. Rivkees, H. Barbhaiya, A. Ijzerman
semanticscholar   +1 more source

Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons

Neural Regeneration Research, 2020
Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.
Yun-Cheng Lv, An-Bo Gao, Jing Yang, Li-Yuan Zhong, Bo Jia, Shu-Hui Ouyang, Le Gui, Tian-Hong Peng, Sha Sun, Francisco S Cayabyab   +9 more
doaj   +1 more source

The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium

Frontiers in Pharmacology, 2022
Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects.
Gabor Viczjan, Gabor Viczjan, Anna Szilagyi, Barbara Takacs, Ignac Ovari, Reka Szekeres, Vera Tarjanyi, Tamas Erdei, Vanda Teleki, Judit Zsuga, Zoltan Szilvassy, Bela Juhasz, Balazs Varga, Rudolf Gesztelyi   +13 more
doaj   +1 more source

Sleep Deprivation Increases A1 Adenosine Receptor Binding in the Human Brain: A Positron Emission Tomography Study

Journal of Neuroscience, 2007
It is currently hypothesized that adenosine is involved in the induction of sleep after prolonged wakefulness. This effect is partially reversed by the application of caffeine, which is a nonselective blocker of adenosine receptors.
D. Elmenhorst, P. Meyer, O. Winz, A. Matusch, J. Ermert, H. Coenen, R. Basheer, H. Haas, K. Zilles, A. Bauer   +9 more
semanticscholar   +1 more source

Role of A1 adenosine receptor in cardiovascular diseases: Bridging molecular mechanisms with therapeutic opportunities

Experimental and Molecular Pathology
Adenosine serves as a critical homeostatic regulator, exerting influence over physiological and pathological conditions in the cardiovascular system.
Warisara Parichatikanond, Ratchanee Duangrat, Narawat Nuamnaichati, Supachoke Mangmool   +3 more
doaj   +1 more source

Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

The Journal of Headache and Pain, 2018
Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels ...
Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón, Antoinette MaassenVanDenBrink   +10 more
doaj   +1 more source