Results 41 to 50 of about 401,347 (255)
Cathepsins: a new culprit behind abdominal aortic aneurysm [PDF]
Regenerative Medicine Research, 2013 Abdominal aortic aneurysm (AAA) is a fatal disease defined as an abdominal aortic diameter of 3.0 cm or more, where the abdominal aorta exceeds the normal diameter by more than 50%.
Wang Yi, Tang Chaoshu, Qin Yanwen
doaj +1 more source
Molecules, 2023 Serine protease is linked to a wide range of diseases, prompting the development of robust, selective, and sensitive protease assays and sensing methods.
Phuong Tu Huynh +5 more
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An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum. [PDF]
PLoS ONE, 2013 The two organelles, apicoplast and mitochondrion, of the malaria parasite Plasmodium falciparum have unique morphology in liver and blood stages; they undergo complex branching and looping prior to division and segregation into daughter merozoites ...
Aiman Tanveer +5 more
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Altered Specificity of a AAA+ Protease [PDF]
Molecular Cell, 2007 ClpXP, an ATP-dependent protease, degrades hundreds of different intracellular proteins. ClpX chooses substrates by binding peptide tags, typically displayed at the N or C terminus of the protein to be degraded. Here, we identify a ClpX mutant that displays a 300-fold change in substrate specificity, resulting in decreased degradation of ssrA-tagged ...
Farrell, Christopher M. +2 more
openaire +2 more sources
ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
eLife, 2020 AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase.
Sora Kim +4 more
doaj +1 more source
Abdominal Aortic Aneurysm: Roles of Inflammatory Cells
Frontiers in Immunology, 2021 Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas. Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However, inflammation has been considered as a central player in the development of AAA.
Zhen Yuan +7 more
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ATP hydrolysis tunes specificity of a AAA+ protease
bioRxiv, 2021 In bacteria, AAA+ proteases such as Lon and ClpXP degrade substrates with exquisite specificity. These machines capture the energy of ATP hydrolysis to power unfolding and degradation of target substrates. Here, we show that a mutation in the ATP binding
S. Mahmoud +2 more
semanticscholar +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran +5 more
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Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. [PDF]
, 2020 The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Myasnikov, Alexander +3 more
core +3 more sources
AAA-ATPases in Protein Degradation
Frontiers in Molecular Biosciences, 2017 Proteolytic machineries containing multisubunit protease complexes and AAA-ATPases play a key role in protein quality control and the regulation of protein homeostasis. In these protein degradation machineries, the proteolytically active sites are formed
Ravikiran S. Yedidi +2 more
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