Results 51 to 60 of about 401,347 (255)
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation [PDF]
, 2009 BACKGROUND: Mast cell chymase may participate in the pathogenesis of human abdominal aortic aneurysm (AAA), yet a direct contribution of this serine protease to AAA formation remains unknown.
Ennis, Terri L +13 more
core +1 more source
m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration [PDF]
Cell Research, 2018 The function of mitochondria depends on ubiquitously expressed and evolutionary conserved m-AAA proteases in the inner membrane. These ATP-dependent peptidases form hexameric complexes built up of homologous subunits. AFG3L2 subunits assemble either into homo-oligomeric isoenzymes or with SPG7 (paraplegin) subunits into hetero-oligomeric proteolytic ...
Patron, M., Sprenger, H., Langer, T.
openaire +3 more sources
Pathology, Research and Practice, 2022 Early diagnosis and identification of prognostic markers for ovarian cancer can significantly improve survival and reduce mortality. The role of the YME1L1 signaling axis in genetic alterations and immune infiltration of the tumor microenvironment ...
Wan-Ting Liao +4 more
semanticscholar +1 more source
Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice [PDF]
, 2011 Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions.
Chen, Han +9 more
core +2 more sources
Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice [PDF]
, 2014 Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of which contribute to aortic ...
Baxter, B. Timothy +14 more
core +1 more source
Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]
, 2012 Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Aksam +58 more
core +4 more sources
YoeB toxin is activated during thermal stress. [PDF]
, 2015 Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando +2 more
core +1 more source
Multifunctional Mitochondrial AAA Proteases [PDF]
Frontiers in Molecular Biosciences, 2017 Mitochondria perform numerous functions necessary for the survival of eukaryotic cells. These activities are coordinated by a diverse complement of proteins encoded in both the nuclear and mitochondrial genomes that must be properly organized and maintained.
openaire +3 more sources
Protein unfolding and degradation by the AAA+ Lon protease [PDF]
Protein Science, 2012 AbstractAAA+ proteases employ a hexameric ring that harnesses the energy of ATP binding and hydrolysis to unfold native substrates and translocate the unfolded polypeptide into an interior compartment for degradation. What determines the ability of different AAA+ enzymes to unfold and thus degrade different native protein substrates is currently ...
Eyal, Gur +2 more
openaire +2 more sources
A Peroxisomal Lon Protease and Peroxisome Degradation by Autophagy Play Key Roles in Vitality of Hansenula polymorpha Cells [PDF]
, 2007 In eukaryote cells various mechanisms exist that are responsible for the removal of non-functional proteins. Here we show that in the yeast Hansenula polymorpha (H.
Bener Aksam, Eda +5 more
core +2 more sources