Results 71 to 80 of about 401,347 (255)

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

eLife, 2020
ClpXP is an ATP-dependent protease in which the ClpX AAA+ motor binds, unfolds, and translocates specific protein substrates into the degradation chamber of ClpP. We present cryo-EM studies of the E.
Xue Fei, Tristan A Bell, Simon Jenni, Benjamin M Stinson, Tania A Baker, Stephen C Harrison, Robert T Sauer   +6 more
doaj   +1 more source

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. [PDF]

, 2011
To broadly explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic interaction map (the MITO-MAP) in Saccharomyces cerevisiae.
Cassidy-Stone, Ann, Collins, Sean R, Devay, Rachel M, Hoppins, Suzanne, Hummel, Eric, Lackner, Laura L, Nunnari, Jodi, Schuldiner, Maya, Weissman, Jonathan S, Westermann, Benedikt   +9 more
core   +2 more sources

Sculpting the Proteome with AAA+ Proteases and Disassembly Machines [PDF]

Cell, 2004
Machines of protein destruction-including energy-dependent proteases and disassembly chaperones of the AAA(+) ATPase family-function in all kingdoms of life to sculpt the cellular proteome, ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change are rapidly and properly regulated.
Sauer, Robert T., Bolon, Daniel N., Burton, Briana M., Burton, Randall E., Flynn, Julia M., Grant, Robert A., Hersch, Greg L., Joshi, Shilpa A., Kenniston, Jon A., Levchenko, Igor, Neher, Saskia B., Oakes, Elizabeth S.C., Siddiqui, Samia M., Wah, David A., Baker, Tania A.   +14 more
openaire   +2 more sources

Membrane protein degradation by AAA proteases in mitochondria

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2002
The inner membrane of mitochondria is one of the protein's richest cellular membranes. The biogenesis of the respiratory chain and ATP-synthase complexes present in this membrane is an intricate process requiring the coordinated function of various membrane-bound proteins including protein translocases and assembly factors.
Arnold, I., Langer, T.
openaire   +3 more sources

Autocatalytic Processing of m-AAA Protease Subunits in Mitochondria [PDF]

Molecular Biology of the Cell, 2009
m-AAA proteases are ATP-dependent proteolytic machines in the inner membrane of mitochondria which are crucial for the maintenance of mitochondrial activities. Conserved nuclear-encoded subunits, termed paraplegin, Afg3l1, and Afg3l2, form various isoenzymes differing in their subunit composition in mammalian mitochondria. Mutations in different m-AAA
Koppen, M., Bonn, F., Ehses, S., Langer, T.   +3 more
openaire   +3 more sources

A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine

Nature Communications, 2023
Many AAA+ (ATPases associated with diverse cellular activities) proteins function as protein or DNA remodelers by threading the substrate through the central pore of their hexameric assemblies.
Shanshan Li, Kan-Yen Hsieh, Chiao-I Kuo, Tzu-Chi Lin, Szu-Hui Lee, Yi-Ru Chen, Chun-Hsiung Wang, Meng-Ru Ho, See-Yeun Ting, Kaiming Zhang, Chung-I Chang   +10 more
doaj   +1 more source

The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly.

Plant Physiology, 2021
ATP is generated in mitochondria by oxidative phosphorylation. Complex I (NADH:ubiquinone oxidoreductase or NADH dehydrogenase) is the first multisubunit protein complex of this pathway, oxidising NADH and transferring electrons to the ubiquinone pool ...
A. Ivanova, Abi S. Ghifari, O. Berkowitz, J. Whelan, M. Murcha   +4 more
semanticscholar   +1 more source

Analysis of the molecular mobility of collagen and elastin in safe, atheromatous and aneurysmal aortas [PDF]

, 2012
Aim of the study : In this study, we propose to use a thermal technique, Differential Scanning Calorimetry (DSC) to follow the evolution of elastin and collagen in safe and pathological cardiovascular tissues.
Dandurand, Jany, Degani, Annamaria, Gandaglia, Alessandro, Gargiulo, Mauro, Lacabanne, Colette, Samouillan, Valérie, Spina, Michel, Stella, Andréa   +7 more
core   +2 more sources

Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells.

PLoS ONE, 2011
Reactive gliosis is a hallmark of many retinal neurodegenerative conditions, including glaucoma. Although a majority of studies to date have concentrated on reactive gliosis in the optic nerve head, very few studies have been initiated to investigate the
Bhagyalaxmi S Ganesh, Shravan K Chintala
doaj   +1 more source

P12 Proliferation and Procoagulant Activity of Vascular Smooth Muscle Cells from Thoracic and Abdominal Aortic Aneurysms

Artery Research, 2020
In contrast to abdominal aortic aneurysm (AAA), aneurysms of the thoracic ascending aorta (TAA) are not associated with a mural thrombus. Mechanistic understanding of the involvement of vascular smooth muscle cells (VSMCs) in thrombus formation is ...
Melusine Didelot, Jeremy Lagrange, Jean-Baptiste Michel, Patrick Lacolley, Veronique Regnault   +4 more
doaj   +1 more source