Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis
mBio, 2023 Bacterial AAA+ unfoldases are crucial for bacterial physiology by recognizing specific substrates and, typically, unfolding them for degradation by a proteolytic component. The caseinolytic protease (Clp) system is one example where a hexameric unfoldase
Stefan Pan +7 more
doaj +1 more source
Proteolytic control of mitochondrial protein translocases. [PDF]
Protein SciAbstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Kroczek L, Langer T.
europepmc +2 more sources
Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses [PDF]
, 2016 ACKNOWLEDGMENTS We thank Dennis Winge (University of Utah) and the members of the Khalimonchuk laboratory for critical comments. We also thank Christoph Schuller (University of Natural Resources, Austria) and Paul Herman (Ohio State University) for ...
Barrientos, Antoni +10 more
core +2 more sources
eLife, 2020 Cells have evolved specialized protein disaggregases to reverse toxic protein aggregation and restore protein functionality. In nonmetazoan eukaryotes, the AAA+ disaggregase Hsp78 resolubilizes and reactivates proteins in mitochondria. Curiously, metazoa
Ryan R Cupo, James Shorter
doaj +1 more source
Protein Processing in Plant Mitochondria Compared to Yeast and Mammals
Frontiers in Plant Science, 2022 Limited proteolysis, called protein processing, is an essential post-translational mechanism that controls protein localization, activity, and in consequence, function. This process is prevalent for mitochondrial proteins, mainly synthesized as precursor
Malgorzata Heidorn-Czarna +2 more
doaj +1 more source
Funktion der m-AAA-Protease bei der Regulation mitochondrialer Translation [PDF]
, 2005 Proteolytische Prozesse spielen bei der Qualitätskontrolle mitochondrialer Proteine und der Biogenese von Mitochondrien eine wichtige Rolle. So führt eine Inaktivierung der ATP-abhängigen m-AAA-Protease in verschiedenen Organismen zu einer gestörten ...
Nolden, Mark
core
Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex [PDF]
, 2014 Gram-negative bacteria use the Type VI secretion system (T6SS) to inject toxic proteins into rival bacteria or eukaryotic cells. However, the mechanism of the T6SS is incompletely understood. In the present study, we investigated a conserved component of
Alan R. Prescott +60 more
core +3 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Proteomics of Cytochrome c Oxidase-Negative versus -Positive Muscle Fiber Sections in Mitochondrial Myopathy [PDF]
, 2019 The mosaic distribution of cytochrome c oxidase(+) (COX+) and COX - muscle fibers in mitochondrial disorders allows the sampling of fibers with compensated and decompensated mitochondrial function from the same individual.
Doll, S. +5 more
core +3 more sources
Recognition of misfolded proteins by Lon, a AAA + protease [PDF]
Genes & Development, 2008 Proteins unfold constantly in cells, especially under stress conditions. Degradation of denatured polypeptides by Lon and related ATP-dependent AAA + proteases helps prevent toxic aggregates formation and other deleterious consequences, but how these destructive enzymatic machines distinguish
Eyal, Gur, Robert T, Sauer
openaire +2 more sources