Cryo-EM structure of transmembrane AAA+ protease FtsH in the ADP state [PDF]
Communications Biology, 2022 Liu et. al determine the cryo-EM structure of ADP-bound transmembrane AAA+ protease FtsH and provide insights into conformational switches between different nucleotide states important for ATP hydrolysis by FtsH.
Wu Liu +4 more
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Lon degrades stable substrates slowly but with enhanced processivity, redefining the attributes of a successful AAA+ protease [PDF]
Cell Reports, 2023 Summary: Lon is a widely distributed AAA+ (ATPases associated with diverse cellular activities) protease known for degrading poorly folded and damaged proteins and is often classified as a weak protein unfoldase.
Meghann R. Kasal +6 more
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The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying. [PDF]
PLoS Genetics, 2016 The m-AAA protease preserves proteostasis of the inner mitochondrial membrane. It ensures a functional respiratory chain, by controlling the turnover of respiratory complex subunits and allowing mitochondrial translation, but other functions in ...
Shuaiyu Wang +7 more
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Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis [PDF]
Frontiers in Molecular Biosciences, 2017 Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis ...
Alexander K. W. Elsholz +5 more
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Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP [PDF]
Communications BiologyBacterial AAA+ proteases are composed of a AAA+ partner (e.g., ClpC) and an associated peptidase (e.g., ClpP). They represent ATP-fuelled and self-compartmentalized proteolytic machines that are crucial for stress resistance and virulence.
Stavros Azinas +6 more
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Proteolytic control of mitochondrial protein translocases. [PDF]
Protein SciAbstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Kroczek L, Langer T.
europepmc +2 more sources
Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7. [PDF]
PLoS ONE, 2009 Paraplegin is an m-AAA protease of the mitochondrial inner membrane that is linked to hereditary spastic paraplegias. The gene encodes an FtsH-homology protease domain in tandem with an AAA+ homology ATPase domain.
Tobias Karlberg +6 more
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Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
Nature Communications, 2021 The human mitochondrial protease LONP1 is an AAA+ ATP-dependent quality control protease. Here, the authors present the cryo-EM structures of human LONP1 in three distinct states and provide insights into the mechanism and regulation of this important ...
Mia Shin +7 more
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Cathepsins: a new culprit behind abdominal aortic aneurysm [PDF]
Regenerative Medicine Research, 2013 Abdominal aortic aneurysm (AAA) is a fatal disease defined as an abdominal aortic diameter of 3.0 cm or more, where the abdominal aorta exceeds the normal diameter by more than 50%.
Wang Yi, Tang Chaoshu, Qin Yanwen
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Molecules, 2023 Serine protease is linked to a wide range of diseases, prompting the development of robust, selective, and sensitive protease assays and sensing methods.
Phuong Tu Huynh +5 more
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