AAA Proteases: Guardians of Mitochondrial Function and Homeostasis [PDF]
Cells, 2018 Mitochondria are dynamic, semi-autonomous organelles that execute numerous life-sustaining tasks in eukaryotic cells. Functioning of mitochondria depends on the adequate action of versatile proteinaceous machineries. Fine-tuning of mitochondrial activity
Magdalena Opalińska, Hanna Jańska
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Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines [PDF]
Nature Reviews Microbiology, 2015 To maintain protein homeostasis, AAA+ proteolytic machines degrade damaged and unneeded proteins in bacteria, archaea and eukaryotes. This process involves the ATP-dependent unfolding of a target protein and its subsequent translocation into a self-compartmentalized proteolytic chamber.
Adrian O Olivares +2 more
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ATP hydrolysis tunes specificity of a AAA+ protease. [PDF]
Cell Rep, 2022 SummaryIn bacteria, AAA+ proteases such as Lon and ClpXP degrade substrates with exquisite specificity. These machines capture the energy of ATP hydrolysis to power unfolding and degradation of target substrates. Here, we show that a mutation in the ATP binding site of ClpX shifts protease specificity to promote degradation of normally Lon-restricted ...
Mahmoud SA, Aldikacti B, Chien P.
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A proteomic study of
BMC Microbiology, 2007 Background The influence of the membrane-bound AAA+ protease FtsH on membrane and cytoplasmic proteins of Corynebacterium glutamicum was investigated in this study.
Schluesener Daniela +4 more
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AAA+ protease-adaptor structures reveal altered conformations and ring specialization. [PDF]
Nat Struct Mol Biol, 2022 Abstract ClpAP, a two-ring AAA+ protease, degrades N-end-rule proteins bound by the ClpS adaptor. Here we present high-resolution cryo-EM structures of Escherichia coli ClpAPS complexes, showing how ClpA pore loops interact with the ClpS N-terminal extension (NTE), which is ...
Kim S, Fei X, Sauer RT, Baker TA.
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Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis. [PDF]
J Biol Chem, 2021 Bouchnak I, van Wijk KJ.
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Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. [PDF]
Sci Adv, 2020 Substrate-free and -bound states of Lon reveal distinct operational modes used by the enzyme to process protein substrates.
Shin M +7 more
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Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease. [PDF]
Mol Cell, 2019 Puchades C +5 more
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Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. [PDF]
Science, 2017 Puchades C +6 more
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An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum. [PDF]
PLoS ONE, 2013 The two organelles, apicoplast and mitochondrion, of the malaria parasite Plasmodium falciparum have unique morphology in liver and blood stages; they undergo complex branching and looping prior to division and segregation into daughter merozoites ...
Aiman Tanveer +5 more
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