Results 21 to 30 of about 63,350 (232)
Altered Specificity of a AAA+ Protease [PDF]
Molecular Cell, 2007 ClpXP, an ATP-dependent protease, degrades hundreds of different intracellular proteins. ClpX chooses substrates by binding peptide tags, typically displayed at the N or C terminus of the protein to be degraded. Here, we identify a ClpX mutant that displays a 300-fold change in substrate specificity, resulting in decreased degradation of ssrA-tagged ...
Farrell, Christopher M. +2 more
openaire +2 more sources
ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
eLife, 2020 AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase.
Sora Kim +4 more
doaj +1 more source
Abdominal Aortic Aneurysm: Roles of Inflammatory Cells
Frontiers in Immunology, 2021 Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas. Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However, inflammation has been considered as a central player in the development of AAA.
Zhen Yuan +7 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran +5 more
doaj +1 more source
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. [PDF]
, 2020 The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Myasnikov, Alexander +3 more
core +3 more sources
AAA-ATPases in Protein Degradation
Frontiers in Molecular Biosciences, 2017 Proteolytic machineries containing multisubunit protease complexes and AAA-ATPases play a key role in protein quality control and the regulation of protein homeostasis. In these protein degradation machineries, the proteolytically active sites are formed
Ravikiran S. Yedidi +2 more
doaj +1 more source
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation [PDF]
, 2009 BACKGROUND: Mast cell chymase may participate in the pathogenesis of human abdominal aortic aneurysm (AAA), yet a direct contribution of this serine protease to AAA formation remains unknown.
Ennis, Terri L +13 more
core +1 more source
m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration [PDF]
Cell Research, 2018 The function of mitochondria depends on ubiquitously expressed and evolutionary conserved m-AAA proteases in the inner membrane. These ATP-dependent peptidases form hexameric complexes built up of homologous subunits. AFG3L2 subunits assemble either into homo-oligomeric isoenzymes or with SPG7 (paraplegin) subunits into hetero-oligomeric proteolytic ...
Patron, M., Sprenger, H., Langer, T.
openaire +3 more sources
Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice [PDF]
, 2011 Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions.
Chen, Han +9 more
core +2 more sources
Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice [PDF]
, 2014 Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of which contribute to aortic ...
Baxter, B. Timothy +14 more
core +1 more source