Results 121 to 130 of about 63,350 (232)

The Non-dominant AAA+ Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation

Cell Reports, 2020
Summary: ATP-powered unfoldases containing D1 and D2 AAA+ rings play important roles in protein homeostasis, but uncertainty about the function of each ring remains.
Hema Chandra Kotamarthi, Robert T. Sauer, Tania A. Baker   +2 more
doaj   +1 more source

A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans [PDF]

, 2004
Molting is required for progression between larval stages in the life cycle of nematodes. We have identified four mutant alleles of a <i>Caenorhabditis elegans</i> metalloprotease gene, <i>nas-37</i>, that cause incomplete ...
Birnie, A.J., Chan, A.C., Davis, M.W., Jorgensen, A.M., Page, A.P.   +4 more
core   +1 more source

Pangenome analysis reveals the genetic mechanism underlying high‐altitude adaptation in Qinghai–Xizang (Tibet) Plateau Rhododendron

Journal of Integrative Plant Biology, EarlyView.
Pan‐genome analysis reveals that high‐altitude Rhododendron species resist alpine cold stress by rapidly sensing and engaging the chilling response pathway and genes that directly and indirectly protect the plant from UV radiation. Heritable genomic features such as long terminal repeats contribute to the adaptive diversification of Rhododendron ...
Haoyang Zhou, Zhongping Xu, Fanhuang Zeng, Haiyu Sang, Zhenhua Liu, Miao Sun, Qiang Fu, Kaige Zhao, Daming Tan, Manzhu Bao, Shuangxia Jin, Xiuqun Liu   +11 more
wiley   +1 more source

Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]

, 2017
The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D, Komives, Elizabeth A, West, Alan MV   +2 more
core   +2 more sources

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Reviewing progress: 7 Year Trends in Characteristics of Adults and Children Enrolled at HIV Care and Treatment Clinics in the United Republic of Tanzania. [PDF]

, 2013
To evaluate the on-going scale-up of HIV programs, we assessed trends in patient characteristics at enrolment and ART initiation over 7 years of implementation. Data were from Optimal Models, a prospective open cohort study of HIV-infected (HIV+) adults (
A Anema, AA Ahonkhai, Ahmed Khatib, AN Kiragga, Annette Almeida, BH Lambdin, Bonita Kilama, C Gwynn, C Hawkins, C Kouanfack, C Tayla, EH Geng, Elaine J Abrams, G Somi, Gongo Ramadhani, Gretchen Antelman, H Nuwagaba-Biribonwoha, H Nuwagaba-Biribonwoha, Harriet Nuwagaba-Biribonwoha, ICAP, Columbia University, J Birungi, J Wachira, Joint United Nations Programme on HIV/AIDS (UNAIDS), K Koo, K Peltzer, M Lahuerta, M Lahuerta, M Lahuerta, M Reece, Matthew R Lamb, National AIDS Control Program (NACP), National AIDS Control Program (NACP), National AIDS Control Program (NACP), O Keiser, P Young, Redempta Mbatia, S Baveewo, S Boyer, S Moon, S Saito, SF Mugusi, SN Duda, Tanzania Commission for AIDS (TACAIDS), Tanzania Commission for AIDS (TACAIDS), Zanzibar AIDS Commission (ZAC), National Bureau of Statistics (NBS), Office of the Chief Government Statistician (OCGS), and Macro International Inc, TD Moon, The United Republic of Tanzania Ministry of Health and Social Welfare, TREAT Asia Pediatric HIV Observational Database (TApHOD), William Reidy, World Health Organisation (WHO), World Health Organisation (WHO), World Health Organization (WHO)   +50 more
core   +3 more sources

An in‐house nucleic acid test for detection of Anaplasma phagocytophilum in whole blood donor samples

Transfusion, EarlyView.
Abstract Background Anaplasma phagocytophilum is a tick‐borne pathogen that causes anaplasmosis. Increased incidences of this disease in Canada and cases of transfusion‐transmitted anaplasmosis in the United States have been reported. Currently, there are no Health Canada licensed methodologies available for detection of A.
Dilini Kumaran, Carmen Charlton, Chantale Pambrun, Steven J. Drews, Sandra Ramirez‐Arcos   +4 more
wiley   +1 more source

Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

Current Research in Structural Biology, 2019
Energy-dependent Lon proteases play a key role in cellular regulation by degrading short-lived regulatory proteins and misfolded proteins in the cell. The structure of the catalytically inactive S679A mutant of Escherichia coli LonA protease (EcLon) has ...
Istvan Botos, George T. Lountos, Weimin Wu, Scott Cherry, Rodolfo Ghirlando, Arsen M. Kudzhaev, Tatyana V. Rotanova, Natalia de Val, Joseph E. Tropea, Alla Gustchina, Alexander Wlodawer   +10 more
doaj   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation [PDF]

, 2016
Initiation of DNA replication depends upon recognition of genomic sites, termed origins, by AAA+ ATPases. In prokaryotes a single factor binds each origin, whereas in eukaryotes this role is played by a six-protein origin recognition complex (ORC).
Damasceno, Jeziel D., Lemgruber Soares, Leandro, Marcello, Lucio, Marques, Catarina A., McCulloch, Richard, Paape, Daniel, Scott, Alan, Tiengwe, Calvin   +7 more
core   +3 more sources